The role of microRNAs in liver cancer progression
Shenglin Huang,X He +1 more
TLDR
Current knowledge about the roles and validated targets of miRNAs in liver cancer progression is summarised.Abstract:
Primary liver cancer, predominantly consisting of hepatocellular carcinoma (HCC), is one of the most common and aggressive human malignancies worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post-transcriptionally. Emerging evidence indicates that miRNAs are often deregulated in HCC, and that some specific miRNAs are associated with the clinicopathological features of HCC. Recent work demonstrates that miRNAs have essential roles in HCC progression and directly contribute to cell proliferation, avoidance of apoptotic cell death, and metastasis of HCC by targeting a large number of critical protein-coding genes. The discovery of the aberrantly expressed miRNAs and their corresponding targets has opened a novel avenue to investigate the molecular mechanism of HCC progression and to develop potential therapeutics against HCC. In this review, we summarise current knowledge about the roles and validated targets of miRNAs in liver cancer progression.read more
Citations
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Cellular and molecular mechanisms of hepatocellular carcinoma: an update.
TL;DR: The current knowledge of HCC is discussed, focusing mainly on advances that have occurred during the past 5 years and on the development of novel therapeutics for liver cancer.
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MicroRNAs and cancer
TL;DR: The review is devoted to analyzing the data on the role of microRNAs in human tumor progression and their participation in the processes responsible for the transformed phenotype of tumor cells.
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MicroRNAs as therapeutic targets in cancer
TL;DR: A review of the current knowledge of miRNAs in both solid and hematological malignancies with a focus on their potential application as therapeutic targets in cancer.
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MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma
Tsung-Chieh Shih,Yin-Jing Tien,Chih-Jen Wen,Ta-Sen Yeh,Ming-Chin Yu,Chia-Hao Huang,Yun-Shien Lee,Tzu-Chen Yen,Sen-Yung Hsieh,Sen-Yung Hsieh +9 more
TL;DR: Downregulation of miR-214 contributes to the unusual hypervascularity of HCC via activation of the HDGF paracrine pathway for tumor angiogenesis and a novel role of microRNA in tumorigenesis is identified.
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MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma
TL;DR: Serum levels of liver enzymes provide insight into liver function and are used during treatment of liver disease, but such information is limited and more sensitive biomarkers may help to achieve earlier detection of neoplastic changes preceding HCC.
References
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Lin He,Gregory J. Hannon +1 more
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