Journal ArticleDOI
The role of NADPH oxidases in neuronal development.
Aslihan Terzi,Daniel M. Suter +1 more
TLDR
The role of Nox-mediated ROS during CNS development is reviewed, which focuses on how individual Nox isoforms contribute to signaling in neural stem cell maintenance and neuronal differentiation, as well as neurite outgrowth and guidance.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2020-07-01. It has received 31 citations till now. The article focuses on the topics: Actin cytoskeleton & Cellular homeostasis.read more
Citations
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Oxidative eustress: On constant alert for redox homeostasis.
TL;DR: In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of the steady-state redox set point, which operates within a physiological range that has been called the "Homeodynamic Space", the "Goldilocks Zone" or the "Golden Mean".
Journal ArticleDOI
Magnetic field effects in biology from the perspective of the radical pair mechanism
TL;DR: An explanation based on the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of transient radical molecules, is suggested for magnetic field effects on various physiological functions as well as isotope effects.
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Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.
TL;DR: In this article, the effects of hypomagnetic field exposure on adult hippocampal neurogenesis and hippocampus-dependent learning were investigated in male C57BL/6'J mice.
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Rare Earth Smart Nanomaterials for Bone Tissue Engineering and Implantology: Advances, Challenges, and Prospects
TL;DR: This review attempted to provide an overview of RE nanomaterials' technological innovations in bone tissue engineering and implantology and summarized the osteogenic, angiogenic, immunomodulatory, antioxidant, in vivo bone tissue imaging, and antimicrobial properties of various RE nanmaterials, as well as the molecular mechanisms involved in these biological events.
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A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury
Ziming Li,Tengfei Zhao,Jie Ding,Haochen Gu,Qiaoxuan Wang,Yifan Wang,Deteng Zhang,Changyou Gao +7 more
TL;DR: In this article , a thioketal-containing and ROS-scavenging hydrogel was prepared for encapsulation of the bone marrow derived mesenchymal stem cells (BMSCs), which promoted the neurogenesis and axon regeneration by scavenging the overproduced reactive oxygen species (ROS) produced by the infiltrated inflammatory immune cells and released to the extracellular microenvironment, leading to widespread apoptosis of the neuron cells, glial and oligodendroctyes.
References
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Journal ArticleDOI
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
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Oxidative Stress and Antioxidant Defense
TL;DR: In this review, the cellular oxidant and antioxidant systems are summarized and the cellular effects and mechanisms of the oxidative stress are discussed.
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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
TL;DR: The role of reactive oxygen species (ROS) as signaling molecules in starvation‐induced autophagy is described and a cysteine residue located near the HsAtg4 catalytic site is specified as a critical for this regulation.
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Cellular mechanisms and physiological consequences of redox-dependent signalling
Kira M. Holmström,Toren Finkel +1 more
TL;DR: The sources of ROS within cells and what is known regarding how intracellular oxidant levels are regulated are discussed, with the recent observations that reduction–oxidation (redox)-dependent regulation has a crucial role in an ever-widening range of biological activities.
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Chemistry and biology of reactive oxygen species in signaling or stress responses
TL;DR: This Perspective provides a focused discussion on what factors lead ROS molecules to become signal and/or stress agents, highlighting how increasing knowledge of the underlying chemistry of ROS can lead to advances in understanding their disparate contributions to biology.