The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor–associated factor 3 (TRAF3)
Dia C. Beachboard,Moonhee Park,Madhuvanthi Vijayan,Daltry L. Snider,Dillon J. Fernando,Graham D. Williams,Sydney Stanley,Michael J. McFadden,Stacy M. Horner +8 more
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TLDR
It is concluded that RAB1B regulates TRAF3 and promotes the formation of innate immune signaling complexes in response to nucleic acid sensing during RNA virus infection.About:
This article is published in Journal of Biological Chemistry.The article was published on 2019-09-27 and is currently open access. It has received 17 citations till now. The article focuses on the topics: TRAF3 & Pattern recognition receptor.read more
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Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection
Nandan S. Gokhale,Alexa B. R. McIntyre,Melissa D. Mattocks,Christopher L. Holley,Helen M. Lazear,Christopher E. Mason,Stacy M. Horner +6 more
TL;DR: Analysis of the transcriptome following infection by dengue virus, Zika virus, West Nile virus, and hepatitis C virus found that infection by these viruses alters m6A modification of specific cellular transcripts, including RIOK3 and CIRBP.
Journal ArticleDOI
The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes.
TL;DR: CMTR1 is required to establish an antiviral state by ensuring the protein expression of a subset of ISGs during the type I IFN response, and plays a role in restricting RNA virus replication.
Journal ArticleDOI
Golgi Apparatus: An Emerging Platform for Innate Immunity
TL;DR: The emerging knowledge about the roles of the Golgi in the initiation and activation of innate immune signaling is reviewed and microbial hijacking strategies that inhibit Golgi-associated innate immune responses will be discussed.
Journal ArticleDOI
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing.
TL;DR: Lee et al. as mentioned in this paper focused on the current state of knowledge regarding key host factors that regulate innate immune signaling molecules upon viral infection and discussed evidence showing how specific viral proteins counteract antiviral responses via immunomodulatory strategies.
Journal ArticleDOI
Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation
Nan Chiang,Xavier de la Rosa,Stephania Libreros,Hui Pan,Jonathan M. Dreyfuss,Charles N. Serhan +5 more
TL;DR: In this paper, the authors sought evidence for cysteinyl-specialized proresolving mediators (cys-SPMs) activation of primordial pathways in planaria regeneration that might link resolution of inflammation and regeneration.
References
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Le Cong,F. A. Ran,David Benjamin Turitz Cox,Shuailiang Lin,Robert P. J. Barretto,Naomi Habib,Patrick D. Hsu,Xuebing Wu,Wenyan Jiang,Luciano A. Marraffini,Feng Zhang +10 more
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