Journal ArticleDOI
The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer
Graeme J.K. Guthrie,Kellie A. Charles,Campbell S.D. Roxburgh,Paul G. Horgan,Donald C. McMillan,Stephen Clarke +5 more
TLDR
The present systematic review examines and comments on the clinical utility of the neutrophil-lymphocyte ratio, which has shown that NLR is elevated in patients with more advanced or aggressive disease evidenced by increased tumour stage, nodal stage, number of metastatic lesions and as such these patients may represent a particularly high-risk patient population.Abstract:
There is increasing and consistent evidence that cancer-associated inflammation is a key determinant of outcome in patients with cancer. Various markers of inflammation have been examined over the past decade in an attempt to refine stratification of patients to treatment and predict survival. One routinely available marker of the systemic inflammatory response is the neutrophil-lymphocyte ratio (NLR), which is derived from the absolute neutrophil and absolute lymphocyte counts of a full blood count. To date, over 60 studies (>37,000 patients) have examined the clinical utility of the NLR to predict patient outcomes in a variety of cancers. The present systematic review examines and comments on the clinical utility of the NLR. The NLR had independent prognostic value in (a) unselected cohorts (1 study of >12,000 patients), (b) operable disease (20 studies, >4000 patients), (c) patients receiving neoadjuvant treatment and resection (5 studies, >1000 patients), (d) patients receiving chemo/radiotherapy (12 studies, >2000 patients) and (e) patients with inoperable disease (6 studies, >1200 patients). These studies originated from ten different countries, in particular UK, Japan, and China. Further, correlative studies (15 studies, >8500 patients) have shown that NLR is elevated in patients with more advanced or aggressive disease evidenced by increased tumour stage, nodal stage, number of metastatic lesions and as such these patients may represent a particularly high-risk patient population. Further studies investigating the tumour and host-derived factors regulating the systemic inflammatory response, in particular the NLR, may identify novel treatment strategies for patients with cancer.read more
Citations
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Journal ArticleDOI
Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis
Arnoud J. Templeton,Mairéad G McNamara,Bostjan Seruga,Francisco E. Vera-Badillo,Priya Aneja,Alberto Ocaña,Raya Leibowitz-Amit,Guru Sonpavde,Jennifer J. Knox,Ben Tran,Ian F. Tannock,Eitan Amir +11 more
TL;DR: A high NLR is associated with an adverse OS in many solid tumors, and its addition to established prognostic scores for clinical decision making warrants further investigation.
Journal ArticleDOI
Cancer-related inflammation and treatment effectiveness
TL;DR: The complex interplay between local immune responses and systemic inflammation, and their influence on clinical outcomes, are examined, and potential anti-inflammatory interventions for patients with cancer are proposed.
Journal ArticleDOI
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
TL;DR: How a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment is discussed.
Journal ArticleDOI
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
TL;DR: The concept of neutrophils phenotypic and functional heterogeneity is presented and several neutrophil subpopulations reported to date are described and the role these sub Populations seem to play in homeostasis and disease is discussed.
Journal ArticleDOI
Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19.
Yuwei Liu,Xuebei Du,Jing Chen,Yalei Jin,Li Peng,Harry H.X. Wang,Harry H.X. Wang,Harry H.X. Wang,Mingqi Luo,Ling Chen,Yan Zhao +10 more
TL;DR: NLR is an independent risk factor of the in-hospital mortality for COVID-19 patients especially for male, and assessment of NLR may help identify high risk individuals with CO VID-19.
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Journal Article
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TL;DR: In the population of 90 ICU oncological patients, rapid serial changes in white blood cell populations are observed, as a response of the immune system to surgical stress, systemic inflammation or sepsis.