The Three-dimensional Structure of the Liver X Receptor β Reveals a Flexible Ligand-binding Pocket That Can Accommodate Fundamentally Different Ligands
Mathias Färnegårdh,Tomas Bonn,Sherry Sun,Jan Ljunggren,Harri Ahola,Anna Wilhelmsson,Jan-Åke Gustafsson,Mats Carlquist +7 more
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TLDR
The structures of the liver X receptor LXRβ (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 Å, respectively, revealing a flexible ligand-binding pocket that can adjust to accommodate fundamentally different ligands.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-10-03 and is currently open access. It has received 154 citations till now.read more
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Principles for modulation of the nuclear receptor superfamily
TL;DR: This review provides a general overview of the mechanism of action of nuclear receptors and explores the various factors that are instrumental in modulating their pharmacology.
Journal ArticleDOI
Liver X receptor biology and pharmacology: new pathways, challenges and opportunities
TL;DR: The current status of the understanding of the LXR biology and pharmacology is discussed, with an emphasis on the molecular aspects of LXR signaling that constitute the potential of LXRs as drug targets.
Journal ArticleDOI
Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
Isabelle M. L. Billas,Thomas Iwema,Jean-Marie Garnier,Andre Mitschler,Natacha Rochel,Dino Moras +5 more
TL;DR: In this article, the ligand-binding domains of the moth Heliothis virescens EcR-USP heterodimer in complex with the ecdysteroid ponasterone A and with a non-steroidal, lepidopteran-specific agonist BYI06830 used in agrochemical pest control.
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Nuclear Receptors and Their Selective Pharmacologic Modulators
Thomas P. Burris,Laura A. Solt,Yongjun Wang,Christine Crumbley,Subhashis Banerjee,Kristine Griffett,Thomas Lundasen,Travis S. Hughes,Douglas J. Kojetin +8 more
TL;DR: The development and pharmacology of a range of selective nuclear receptor modulators are reviewed, where ligands display agonist/partial agonist-binding domain of nuclear receptors function in a tissue or gene selective manner.
Journal ArticleDOI
Crystal structure of a zinc-finger–RNA complex reveals two modes of molecular recognition
TL;DR: The crystal structure of a three-finger complex with 61 bases of RNA, derived from the central regions of the complete nine-finger TFIIIA–5S RNA complex, reveals two modes of zinc-finger binding, both of which differ from that in common use for DNA.
References
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