Journal ArticleDOI
The ventralizing effect of the notochord on somite differentiation in chick embryos
TLDR
The notochord is found to exert a ventralizing effect on the establishment of the dorso-ventral pattern in the somites, and a widening of the Pax-1-expressing domain in the sclerotome can be observed.Abstract:
The dorso-ventral pattern formation of the somites becomes manifest by the formation of the epithelially organized dorsal dermomyotome and the mesenchymal ventrally situated sclerotome. While the dermomyotome gives rise to dermis and muscle, the sclerotome differentiates into cartilage and bone of the axial skeleton. The onset of muscle differentiation can be visualized by immunohistochemistry for proteins associated with muscle contractility, e.g. desmin. The sclerotome cells and the epithelial ventral half of the somite express Pax-1, a member of a gene family with a sequence similarity to Drosophila paired-box-containing genes. In the present study, changes of Pax-1 expression were studied after grafting an additional notochord into the paraxial mesoderm region. The influence of the notochord and the floor-plate on dermomyotome formation and myotome differentiation has also been investigated. The notochord is found to exert a ventralizing effect on the establishment of the dorso-ventral pattern in the somites. Notochord grafts lead to a suppression of the formation and differentiation of the dorsal somitic derivatives. Simultaneously, a widening of the Pax-1-expressing domain in the sclerotome can be observed. In contrast, grafted roof-plate and aorta do not interfere with dorso-ventral patterning of the somitic derivatives.read more
Citations
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Journal ArticleDOI
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
TL;DR: The cellular interactions that control the differentiation of dorsal cell types from neural progenitors have been examined in neural plate explants and appear to be initiated at the neural plate stage and to involve the opponent activities of a BMP-mediated dorsalizing signal from the epidermal ectoderm and a SHH-mediated ventralizing signalFrom the notochord.
MonographDOI
Primer on the metabolic bone diseases and disorders of mineral metabolism
John P. Bilezikian,Roger Bouillon,Thomas L. Clemens,Juliet E. Compston,Douglas C. Bauer,Peter R. Ebeling,Klaus Engelke,David Goltzman,Theresa A. Guise,Suzanne M. Jan de Beur,Harald Jüppner,Karen M. Lyons,Laurie K. McCauley,Michael R. McClung,Paul D. Miller,Socrates E. Papapoulos,G. David Roodman,Clifford J. Rosen,Ego Seeman,Ego Seeman,Rajesh V. Thakker,Michael P. Whyte,Michael P. Whyte,Mone Zaidi +23 more
TL;DR: This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats.
Book ChapterDOI
Developmental roles and clinical significance of hedgehog signaling.
TL;DR: This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these, and the increasing significance of Hedge Hog signaling in the clinical setting.
Journal ArticleDOI
The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo
Daniel C. Weinstein,Ariel Ruiz i Altaba,William S. Chen,Pamela A. Hoodless,Vincent R. Prezioso,Thomas M. Jessell,James E. Darnell +6 more
TL;DR: It is shown that HNF-3 beta has an essential role in the development of axial mesoderm in mouse embryos and marked defects in the organization of somites and neural tube that may result from the absence of the notochord.
Journal ArticleDOI
Early stages of chick somite development
Bodo Christ,Charles P. Ordahl +1 more
TL;DR: The formation and early differentiation of the somites in the avian embryo is reported on and a method for staging somites according to their developmental age is suggested.
References
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Journal ArticleDOI
Pax-6, a murine paired box gene, is expressed in the developing CNS.
Claudia Walther,Peter Gruss +1 more
TL;DR: The expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region are described and, in addition to the paired domain, a paired-type homeodomain is contained.
Journal ArticleDOI
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid
Michael Kessel,Peter Gruss +1 more
TL;DR: It is suggested that the identity of a vertebral segment is specified by a combination of functionally active Hox genes, a "Hox code," and that exogenous RA interferes with the normal establishment of Hox codes and thus with axial specification.
Journal ArticleDOI
Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord.
Toshiya Yamada,Toshiya Yamada,Marysia Placzek,H. Tanaka,Jane Dodd,Thomas M. Jessell,Thomas M. Jessell +6 more
TL;DR: Evidence is provided that the pattern of cell differentiation along the dorsoventral axis of the chick neural tube is regulated by signals derived from two ventral midline cell groups, the notochord and floor plate.
Journal ArticleDOI
Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3.
TL;DR: This study provides evidence for a causal link between deletion of the paired homeodomain of PAX-3 and the Sp2H mutation, and infers that Pax-3 plays a key role in normal neural development.
Journal ArticleDOI
Genetical studies on the skeleton of the mouse
TL;DR: The tail anomalies are produced mechanically either by spina bifida which persists, or by a rudimentary form of it (delayed closure of the posterior neuropore) which is transitory as mentioned in this paper.