Open AccessJournal Article
Therapeutic application of mesenchymal stem cell-derived exosomes: A promising cell-free therapeutic strategy in regenerative medicine.
Mahsa Motavaf,Katayoon Pakravan,Sadegh Babashah,F Malekvandfard,Mahbobeh Masoumi,Majid Sadeghizadeh +5 more
TLDR
The current literature on administration of exosomes released by mesenchymal stem cells in regenerative medicine is summarized and how they could help to improve tissue regeneration following injury is suggested.Abstract:
Mesenchymal stem cells have emerged as promising therapeutic candidates in regenerative medicine. The mechanisms underlying mesenchymal stem cells regenerative properties were initially attributed to their engraftment in injured tissues and their subsequent transdifferentiation to repair and replace damaged cells. However, studies in animal models and patients indicated that the low number of transplanted mesenchymal stem cells localize to the target tissue and transdifferentiate to appropriate cell lineage. Instead the regenerative potential of mesenchymal stem cells has been found - at least in part - to be mediated via their paracrine actions. Recently, a secreted group of vesicles, called "exosome" has been identified as major mediator of mesenchymal stem cells therapeutic efficacy. In this review, we will summarize the current literature on administration of exosomes released by mesenchymal stem cells in regenerative medicine and suggest how they could help to improve tissue regeneration following injury.read more
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Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis.
Na Wang,Caiyu Chen,Dezhong Yang,Qiao Liao,Hao Luo,Xinquan Wang,Faying Zhou,Xiaoli Yang,Jian Yang,Chunyu Zeng,Wei Eric Wang +10 more
TL;DR: MSC-EVs are sufficient to improve angiogenesis and exert therapeutic effect on MI, its pro-angiogenesis effect might be associated with a miR-210-Efna3 dependent mechanism.
Journal ArticleDOI
Exosomes derived from pro-inflammatory bone marrow-derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization.
Ruqin Xu,Fangcheng Zhang,Renjie Chai,Wenyi Zhou,Ming Hu,Bin Liu,Xuke Chen,Mingke Liu,Qiong Xu,Ningning Liu,Shiming Liu +10 more
TL;DR: It is found that exosomes derived from BMSCs, in both Exo and L‐Exo groups, increased M2 macrophage polarization and decreased M1 macrophages polarization under LPS stimulation, which strongly depressed LPS‐dependent NF‐κB signalling pathway and partly activated the AKT1/AKT2 signalling pathway.
Journal ArticleDOI
Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease.
Abbas Shapouri Moghaddam,Jalil Tavakol Afshari,Seyed-Alireza Esmaeili,Ehsan Saburi,Zeinab Joneidi,Amir Abbas Momtazi-Borojeni +5 more
TL;DR: Cardioprotective exosomal miRs secreted by transplanted stem cells from various sources, including embryonic stem cells, induced pluripotent stem cells (iPSCs), mesenchymalstem cells (MSCs), and cardiac stem/progenitor cells, showed beneficial modulatory effects on the myocardial infracted heart.
Journal ArticleDOI
A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine.
Soudeh Moghadasi,Marischa Elveny,Heshu Sulaiman Rahman,Heshu Sulaiman Rahman,Wanich Suksatan,Abduladheem Turki Jalil,Walid Kamal Abdelbasset,Walid Kamal Abdelbasset,Alexei Valerievich Yumashev,Siavash Shariatzadeh,Roza Motavalli,Farahnaz Behzad,Faroogh Marofi,Ali Hassanzadeh,Yashwant Pathak,Mostafa Jarahian +15 more
TL;DR: In this article, mesenchymal stem/stromal cells (MSCs) exosomes are used to convey functional molecules such as long non-coding RNAs (lncRNAs) and micro-RNAs (miRNAs), proteins (e.g., chemokine and cytokine), and lipids from MSCs to target cells.
Journal ArticleDOI
microRNA-141-3p-containing small extracellular vesicles derived from epithelial ovarian cancer cells promote endothelial cell angiogenesis through activating the JAK/STAT3 and NF-κB signaling pathways
TL;DR: A novel model is proposed in which sEV transfer of epithelial ovarian cancer-secreted miR-141-3p plays as a significant mediator of intercellular communication, promoting endothelial cell angiogenesis.
References
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Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
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B lymphocytes secrete antigen-presenting vesicles.
Graça Raposo,Hans W. Nijman,Willem Stoorvogel,R Liejendekker,Clifford V. Harding,Cornelis J. M. Melief,Hans J. Geuze +6 more
TL;DR: It is demonstrated by immunoelectron microscopy that the limiting membrane of MIICs can fuse directly with the plasma membrane, resulting in release from the cells of internal MHC class II-containing vesicles, suggesting a role for exosomes in antigen presentation in vivo.
Journal ArticleDOI
Mesenchymal stem cells as trophic mediators.
Arnold I. Caplan,James E. Dennis +1 more
TL;DR: Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of M SC‐mediated trophic effects in tissue repair.
Journal ArticleDOI
Adult rat and human bone marrow stromal cells differentiate into neurons
TL;DR: Adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases.
Journal ArticleDOI
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry,Mark H. Soonpaa,Hans Reinecke,Hidehiro Nakajima,Hisako O. Nakajima,Michael Rubart,Kishore B.S. Pasumarthi,Kishore B.S. Pasumarthi,Jitka A. I. Virag,Stephen H. Bartelmez,Veronica Poppa,Gillian Bradford,Joshua D. Dowell,David A. Williams,David A. Williams,Loren J. Field +15 more
TL;DR: Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.