Journal ArticleDOI
Thyroid cancer mortality and incidence: A global overview
Carlo La Vecchia,Matteo Malvezzi,Cristina Bosetti,Werner Garavello,Paola Bertuccio,Fabio Levi,Eva Negri +6 more
TLDR
The declines in thyroid cancer mortality reflect both variations in risk factor exposure and changes in the diagnosis and treatment of the disease, while the increases in the incidence are likely due to the increase in the detection of this neoplasm over the last few decades.Abstract:
In most areas of the world, thyroid cancer incidence has been appreciably increasing over the last few decades, whereas mortality has steadily declined. We updated global trends in thyroid cancer mortality and incidence using official mortality data from the World Health Organization (1970-2012) and incidence data from the Cancer Incidence in Five Continents (1960-2007). Male mortality declined in all the major countries considered, with annual percent changes around -2/-3% over the last decades. Only in the United States mortality declined up to the mid 1980s and increased thereafter. Similarly, in women mortality declined in most countries considered, with APCs around -2/-5% over the last decades, with the exception of the UK, the United States and Australia, where mortality has been declining up to the late 1980s/late 1990s to level off (or increase) thereafter. In 2008-2012, most countries had mortality rates (age-standardized, world population) between 0.20 and 0.40/100,000 men and 0.20 and 0.60/100,000 women, the highest rates being in Latvia, Hungary, the Republic of Moldova and Israel (over 0.40/100,000) for men and in Ecuador, Colombia and Israel (over 0.60/100,000) for women. In most countries, a steady increase in the incidence of thyroid cancer (mainly papillary carcinomas) was observed in both sexes. The declines in thyroid cancer mortality reflect both variations in risk factor exposure and changes in the diagnosis and treatment of the disease, while the increases in the incidence are likely due to the increase in the detection of this neoplasm over the last few decades.read more
Citations
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SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial-mesenchymal transition.
TL;DR: It is confirmed that the SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing EMT with changes in the EMT associated markers and in the invasion and migration ability were rescued after inhibition of HIF- 1α expression.
Journal ArticleDOI
Altered Epigenetic Mechanisms in Thyroid Cancer Subtypes
Maryam Zarkesh,Azita Zadeh-Vakili,Fereidoun Azizi,Forough Foroughi,Maziar Mohammad Akhavan,Mehdi Hedayati +5 more
TL;DR: Analysis of epigenetic alterations in TC subtypes helps to identify pathogenesis and can play an important role in the classification and diagnosis of tumors.
Journal ArticleDOI
Risk of developing chronic myeloid neoplasms in well-differentiated thyroid cancer patients treated with radioactive iodine
Remco J. Molenaar,Christopher Pleyer,Tomas Radivoyevitch,Surbhi Sidana,Andrew Godley,Anjali S. Advani,Aaron T. Gerds,Hetty E. Carraway,Matt Kalaycio,Aziz Nazha,David J. Adelstein,Christian Nasr,Dana E. Angelini,Jaroslaw P. Maciejewski,Navneet S. Majhail,Mikkael A. Sekeres,Sudipto Mukherjee +16 more
TL;DR: Data suggest that RAI treatment for WDTC is associated with increased risk of MDS with short latency and poor survival, and the increased risk was significantly associated with WDTC size ⩾2 cm or regional disease.
Journal ArticleDOI
CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways.
Shitong Yu,Qian Zhong,Ren Hui Chen,Ping Han,Shi Bing Li,Hua Zhang,Li Yuan,Tian Liang Xia,Mu Sheng Zeng,Xiaoming Huang +9 more
TL;DR: It is suggested that CRLF1 enhances cell proliferation and metastasis in PTC and thus may therefore be a potential therapeutic target for PTC.
Journal Article
The lncRNA n340790 accelerates carcinogenesis of thyroid cancer by regulating miR-1254.
TL;DR: N340790 promoted the development process of malignant thyroid cancer by regulating miR-1254, and targeting n340790 may be a promising strategy as a thyroid cancer therapy.
References
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