Journal ArticleDOI
Thyroid cancer mortality and incidence: A global overview
Carlo La Vecchia,Matteo Malvezzi,Cristina Bosetti,Werner Garavello,Paola Bertuccio,Fabio Levi,Eva Negri +6 more
TLDR
The declines in thyroid cancer mortality reflect both variations in risk factor exposure and changes in the diagnosis and treatment of the disease, while the increases in the incidence are likely due to the increase in the detection of this neoplasm over the last few decades.Abstract:
In most areas of the world, thyroid cancer incidence has been appreciably increasing over the last few decades, whereas mortality has steadily declined. We updated global trends in thyroid cancer mortality and incidence using official mortality data from the World Health Organization (1970-2012) and incidence data from the Cancer Incidence in Five Continents (1960-2007). Male mortality declined in all the major countries considered, with annual percent changes around -2/-3% over the last decades. Only in the United States mortality declined up to the mid 1980s and increased thereafter. Similarly, in women mortality declined in most countries considered, with APCs around -2/-5% over the last decades, with the exception of the UK, the United States and Australia, where mortality has been declining up to the late 1980s/late 1990s to level off (or increase) thereafter. In 2008-2012, most countries had mortality rates (age-standardized, world population) between 0.20 and 0.40/100,000 men and 0.20 and 0.60/100,000 women, the highest rates being in Latvia, Hungary, the Republic of Moldova and Israel (over 0.40/100,000) for men and in Ecuador, Colombia and Israel (over 0.60/100,000) for women. In most countries, a steady increase in the incidence of thyroid cancer (mainly papillary carcinomas) was observed in both sexes. The declines in thyroid cancer mortality reflect both variations in risk factor exposure and changes in the diagnosis and treatment of the disease, while the increases in the incidence are likely due to the increase in the detection of this neoplasm over the last few decades.read more
Citations
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Journal ArticleDOI
Expressions of IL-17 and TNF-α in patients with Hashimoto’s disease combined with thyroid cancer before and after surgery and their relationship with prognosis
TL;DR: IL-17 and TNF-α may be used as potential prognostic indicators of HD patients with TC and are higher than those of healthy control group.
Journal ArticleDOI
Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p.
TL;DR: It is demonstrated that matrine exerts antitumor effects possibly by inducing the apoptosis of TCP-1 and BCPAP cells, decreasing the level of Bcl-2, activating caspase3 and suppressing PTC tumor growth by downregulating the expression of miR-182-5p.
Journal ArticleDOI
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
Ting-Ting Zhang,Ning Qu,Guo Hua Sun,Long Zhang,Yuan Jin Wang,Xiang Ming Mu,Wen Jun Wei,Yu-Long Wang,Yu Wang,Qinghai Ji,Yong Xue Zhu,Rong Liang Shi +11 more
TL;DR: The immuno-histochemical scoring of 196 PTC samples and the analysis of the data of 490 patients from The Cancer Genome Atlas reveled a positive association between the expression of NRG1 and NRF2, which may prove to be a potential therapeutic target in the treatment of thyroid cancer.
Journal ArticleDOI
High iodine intake and central lymph node metastasis risk of papillary thyroid cancer.
TL;DR: High iodine intake appears not to be an initiator, but may be a weak promoter for female PTC progression, which needs further validation.
Journal ArticleDOI
Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells.
Elena Cetti,Tiziana Di Marco,Giuseppe Di Mauro,Mara Mazzoni,Daniele Lecis,Emanuela Minna,Lucia Gioiosa,Silvia Brich,Sonia Pagliardini,Maria Grazia Borrello,Giancarlo Pruneri,Maria Chiara Anania,Angela Greco +12 more
TL;DR: The results demonstrate that MASTL represents vulnerability for thyroid tumor cells, which could be explored as a therapeutic target for thyroid cancer.
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