Journal ArticleDOI
Thyroid cancer mortality and incidence: A global overview
Carlo La Vecchia,Matteo Malvezzi,Cristina Bosetti,Werner Garavello,Paola Bertuccio,Fabio Levi,Eva Negri +6 more
TLDR
The declines in thyroid cancer mortality reflect both variations in risk factor exposure and changes in the diagnosis and treatment of the disease, while the increases in the incidence are likely due to the increase in the detection of this neoplasm over the last few decades.Abstract:
In most areas of the world, thyroid cancer incidence has been appreciably increasing over the last few decades, whereas mortality has steadily declined. We updated global trends in thyroid cancer mortality and incidence using official mortality data from the World Health Organization (1970-2012) and incidence data from the Cancer Incidence in Five Continents (1960-2007). Male mortality declined in all the major countries considered, with annual percent changes around -2/-3% over the last decades. Only in the United States mortality declined up to the mid 1980s and increased thereafter. Similarly, in women mortality declined in most countries considered, with APCs around -2/-5% over the last decades, with the exception of the UK, the United States and Australia, where mortality has been declining up to the late 1980s/late 1990s to level off (or increase) thereafter. In 2008-2012, most countries had mortality rates (age-standardized, world population) between 0.20 and 0.40/100,000 men and 0.20 and 0.60/100,000 women, the highest rates being in Latvia, Hungary, the Republic of Moldova and Israel (over 0.40/100,000) for men and in Ecuador, Colombia and Israel (over 0.60/100,000) for women. In most countries, a steady increase in the incidence of thyroid cancer (mainly papillary carcinomas) was observed in both sexes. The declines in thyroid cancer mortality reflect both variations in risk factor exposure and changes in the diagnosis and treatment of the disease, while the increases in the incidence are likely due to the increase in the detection of this neoplasm over the last few decades.read more
Citations
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Testicular orphan receptor 4 (TR4) promotes papillary thyroid cancer invasion via activating circ-FNLA/miR-149-5p/MMP9 signaling.
TL;DR: Overall, this study pinpoints the oncogenic role of TR4 in PTC development, and the targeting of the TR4/circ-FLNA/miR-149-5p/MMP9 signaling axis may be an alternative option for metastatic PTC patients.
Journal ArticleDOI
Lysophosphatidic Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
TL;DR: Downregulation of LPAR5 expression can inhibit the physiological process of PTC, and this phenomenon is related to the PI3K/AKT pathway and EMT.
Journal ArticleDOI
Thyroid cancer overdiagnosis and overtreatment: a cross- sectional study at a thyroid cancer referral center in Ecuador.
Paola Solis-Pazmino,Jorge Salazar-Vega,Eddy Lincango-Naranjo,C. García,Gabriela Jaramillo Koupermann,Esteban Ortiz-Prado,Tannya Ledesma,Tatiana Rojas,Benjamin Alvarado-Mafla,Cesar Carcamo,Oscar J. Ponce,Oscar J. Ponce,Juan P. Brito +12 more
TL;DR: This monograph aims to provide a history of cancer research in Ecuador and some of the techniques used, as well as some of their applications, that have been developed in recent years.
Journal ArticleDOI
Radiotherapy for childhood cancer and subsequent thyroid cancer risk: a systematic review.
TL;DR: The first systematic literature review on this association between radiotherapy for childhood cancer and an increased thyroid cancer risk is presented combined with a critical assessment of the methodological quality of the included articles.
Journal ArticleDOI
Aberrant expression of tumor-associated carbohydrate antigen Globo H in thyroid carcinoma.
TL;DR: This work aimed to investigate the expression patterns and prognostic value of Globo H in thyroid neoplasms and found that tumor‐associated carbohydrate antigen results from altered glycosylation in transformed cells.
References
More filters
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Cancer statistics, 2014
TL;DR: The magnitude of the decline in cancer death rates from 1991 to 2010 varies substantially by age, race, and sex, ranging from no decline among white women aged 80 years and older to a 55% decline among black men aged 40 years to 49 years.
Journal ArticleDOI
Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
Lola Rahib,Benjamin Smith,Rhonda Aizenberg,Allison B. Rosenzweig,Julie M. Fleshman,Lynn M. Matrisian +5 more
TL;DR: Pancreas and liver cancers are projected to surpass breast, prostate, and colorectal cancers to become the second and third leading causes of cancer-related death by 2030, respectively.
Book
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Richard Doll,Richard Peto +1 more
TL;DR: Evidence that the various common types of cancer are largely avoidable diseases is reviewed, and it is suggested that, apart from cancer of the respiratory tract, the types of cancers that are currently common are not peculiarly modern diseases and are likely to depend chiefly on some long-established factor.
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