TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
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TLDR
expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1803 citations till now. The article focuses on the topics: TP53-inducible glycolysis and apoptosis regulator & Apoptosis Regulator.read more
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Spatial reorganization of Saccharomyces cerevisiae enolase to alter carbon metabolism under hypoxia.
Natsuko Miura,Masahiro Shinohara,Yohei Tatsukami,Yasuhiko Sato,Hironobu Morisaka,Hironobu Morisaka,Kouichi Kuroda,Mitsuyoshi Ueda,Mitsuyoshi Ueda +8 more
TL;DR: The results suggest that under hypoxia, S. cerevisiae cells sense mitochondrial ROS and, by the involvement of SNF1/AMPK, spatially reorganize metabolic enzymes in the cytosol via de novo protein synthesis, which subsequently increases carbon metabolism.
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Uncoupling the Warburg effect from cancer
Ayaz Najafov,Dario R. Alessi +1 more
TL;DR: Recent work by Salvador Moncada's group published in PNAS and other recent work from the same group provides exciting evidence supporting the idea that the Warburg effect is also required for the proliferation of noncancer cells.
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Is p53 Involved in Tissue-Specific Insulin Resistance Formation?
TL;DR: A profound insight is provided into p53-dependent metabolic actions directed towards promotion of insulin resistance as well as presenting experimental data regarding obesity-induced p 53-mediated metabolic abnormalities.
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Three-Dimensional Graphene Enhances Neural Stem Cell Proliferation Through Metabolic Regulation
Qiaojun Fang,Yuhua Zhang,Xiangbo Chen,He Li,Liya Cheng,Wenjuan Zhu,Zhong Zhang,Mingliang Tang,Wei Liu,Hui Wang,Tian Wang,Tie Shen,Renjie Chai +12 more
TL;DR: This study established the correlation between metabolic reconfiguration metabolomics with NSCs cell proliferation rate on different scaffold and suggested a potential association between graphene and pathways involved in Parkinson's disease.
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p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells
TL;DR: Investigation of whether p53 regulates mACON expression and the potential mechanisms responsible for its effect on prostate cancer cells investigate the role of p53 in suppressing prostatic tumorigenesis.
References
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Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Lyubomir T. Vassilev,Binh Thanh Vu,Bradford Graves,Daisy Carvajal,Frank John Podlaski,Zoran Filipovic,Norman Kong,Ursula Kammlott,Christine Lukacs,Christian Klein,Nader Fotouhi,Liu Emily Aijun +11 more
TL;DR: In this article, the authors identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts.
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Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.