TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
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TLDR
expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1803 citations till now. The article focuses on the topics: TP53-inducible glycolysis and apoptosis regulator & Apoptosis Regulator.read more
Citations
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Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney.
Takashi Hato,Allon N. Friedman,Henry E. Mang,Zoya Plotkin,Shataakshi Dube,Gary D. Hutchins,Paul R. Territo,Brian P. McCarthy,Amanda A. Riley,Kumar Pichumani,Craig R. Malloy,Robert A. Harris,Pierre C. Dagher,Timothy A. Sutton +13 more
TL;DR: Evidence is provided that PET is a valuable tool for examining kidney metabolism in preclinical and clinical studies, intravital MPM is a powerful adjunct to PET in pre clinical studies of metabolism, and p53 inhibition alters basal kidney metabolism.
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Loss of mitochondria in ganglioneuromas.
René G. Feichtinger,Daniel Neureiter,Johannes A Mayr,Franz A. Zimmermann,Frank Berthold,Neil Jones,Wolfgang Sperl,Barbara Kofler +7 more
TL;DR: To elucidate changes of the mitochondrial energy metabolism in ganglioneuroma, individual OXPHOS enzymes were analyzed by activity assays and by immunohistochemical staining methods and a striking decline of mitochondrial mass was observed.
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The role of tumor suppressor p53 in metabolism and energy regulation, and its implication in cancer and lifestyle-related diseases.
TL;DR: The importance of multifunctionality of p53, particularly with regard to intracellular metabolisms, arouses therapeutic interest and calls attention as the key molecule among cancer, lifestyle-related diseases and life expectancy.
Journal ArticleDOI
An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation
Zhijie Cao,Ning Kon,Yajing Liu,Wenbin Xu,Jia Wen,Han Yao,Mi Zhang,Zhen Wu,Xiaojun Yan,Wei-Guo Zhu,Wei Gu,Donglai Wang +11 more
TL;DR: Zhang et al. as mentioned in this paper revealed a mechanism for activating cancer cell-intrinsic programmed cell death protein-1 (PD-1) and indicates that p53-mediated PD-1 activation is critically involved in tumor suppression in an immunity-independent manner.
Journal ArticleDOI
Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1.
TL;DR: In this article, the role of nucleoredoxin (NRX) in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway was investigated.
References
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Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Lyubomir T. Vassilev,Binh Thanh Vu,Bradford Graves,Daisy Carvajal,Frank John Podlaski,Zoran Filipovic,Norman Kong,Ursula Kammlott,Christine Lukacs,Christian Klein,Nader Fotouhi,Liu Emily Aijun +11 more
TL;DR: In this article, the authors identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts.
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Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.