TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
Reads0
Chats0
TLDR
expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1803 citations till now. The article focuses on the topics: TP53-inducible glycolysis and apoptosis regulator & Apoptosis Regulator.read more
Citations
More filters
Journal ArticleDOI
The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
TL;DR: The findings reveal mitochondrial oxidative metabolism as a critical suppressor of metastasis and justify metabolic therapies for potential prevention/intervention of tumor metastasis.
Journal ArticleDOI
Coping with stress: multiple ways to activate p53
Henning F. Horn,Karen H. Vousden +1 more
TL;DR: This review will highlight some recently identified roles for p53 in tumour suppression, and discuss some of the numerous mechanisms through which p53 can be regulated and activated.
Journal ArticleDOI
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival
TL;DR: It is now clear that G6PD is under complex regulatory control and of central importance to many cellular processes.
Journal ArticleDOI
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism
Wen Yi,Peter M. Clark,Daniel E. Mason,Marie C. Keenan,Collin Hill,William A. Goddard,Eric C. Peters,Edward M. Driggers,Linda C. Hsieh-Wilson +8 more
TL;DR: It is demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism and was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia.
Journal ArticleDOI
p53 post-translational modification: deregulated in tumorigenesis
TL;DR: The recent advances in understanding of the wide spectrum of post-translational modifications that act as epigenetic-like codes for modulating specific functions of p53 in vivo are reviewed and how deregulation of these modifications might contribute to tumorigenesis are reviewed.
References
More filters
Journal ArticleDOI
Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
Journal ArticleDOI
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Lyubomir T. Vassilev,Binh Thanh Vu,Bradford Graves,Daisy Carvajal,Frank John Podlaski,Zoran Filipovic,Norman Kong,Ursula Kammlott,Christine Lukacs,Christian Klein,Nader Fotouhi,Liu Emily Aijun +11 more
TL;DR: In this article, the authors identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts.
Journal ArticleDOI
Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.