TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
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TLDR
expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1803 citations till now. The article focuses on the topics: TP53-inducible glycolysis and apoptosis regulator & Apoptosis Regulator.read more
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Stressing the role of FoxO proteins in lifespan and disease.
TL;DR: This work has shown that a shared yet opposing regulatory network between FoxO and p53 may underlie a 'trade-off' between disease and lifespan.
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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
TL;DR: Results demonstrated that as a unique p53 target gene, GLS2 is a mediator of p53’s role in energy metabolism and antioxidant defense, which can contribute to its role in tumor suppression.
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ROS and p53: A versatile partnership
TL;DR: The newly discovered role of p53 in regulating cellular ROS generation and how ROS modulate selective transactivation of certain p53 target genes are examined, with a focus on interlinks between ROS and p53.
Journal ArticleDOI
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Rizwan Haq,Jonathan Shoag,Pedro Andreu-Perez,Satoru Yokoyama,Satoru Yokoyama,Hannah E. Edelman,Glenn C. Rowe,Dennie T. Frederick,Aeron D. Hurley,Abhinav Nellore,Andrew L. Kung,Jennifer A. Wargo,Jun S. Song,David E. Fisher,Zolt Arany,Hans R. Widlund +15 more
TL;DR: It is shown that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the increased expression of the mitochondrial master regulator, PGC1α, and a target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression of P GC1α.
Cancer Cell Metabolism: One Hallmark, Many Faces
TL;DR: The diversity of changes within the metabolic program of a cancer cell can dictate by what means proliferative rewiring is driven, and can also impart heterogeneity in the metabolic dependencies of the cell.
References
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Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Lyubomir T. Vassilev,Binh Thanh Vu,Bradford Graves,Daisy Carvajal,Frank John Podlaski,Zoran Filipovic,Norman Kong,Ursula Kammlott,Christine Lukacs,Christian Klein,Nader Fotouhi,Liu Emily Aijun +11 more
TL;DR: In this article, the authors identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts.
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Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.