Journal ArticleDOI
Transcriptional control of early B cell development.
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TLDR
The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple transcription factors regulating distinct developmental aspects, and Pax5 restricts the developmental options of lymphoid progenitors to the B cell lineage.Abstract:
The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple transcription factors regulating distinct developmental aspects. Ikaros and PU.1 act in parallel pathways to control the development of lymphoid progenitors in part by regulating the expression of essential signaling receptors (Flt3, c-Kit, and IL-7Rα). The generation of the earliest B cell progenitors depends on E2A and EBF, which coordinately activate the B cell gene expression program and immunoglobulin heavy-chain gene rearrangements at the onset of B-lymphopoiesis. Pax5 restricts the developmental options of lymphoid progenitors to the B cell lineage by repressing the transcription of lineage-inappropriate genes and simultaneously activating the expression of B-lymphoid signaling molecules. LEF1 and Sox4 contribute to the survival and proliferation of pro-B cells in response to extracellular signals. Finally, IRF4 and IRF8 together control the termination of pre-B cell receptor signaling and thus promote different...read more
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Journal ArticleDOI
Super-Enhancers in the Control of Cell Identity and Disease
Denes Hnisz,Brian J. Abraham,Tong Ihn Lee,Ashley Lau,Violaine Saint-André,Alla A. Sigova,Heather A. Hoke,Richard A. Young +7 more
TL;DR: The super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity and play key roles in human cell identity in health and in disease as mentioned in this paper.
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Regulation and Function of NF-κB Transcription Factors in the Immune System
TL;DR: Much progress has been made in the past two years revealing new insights into the regulation and functions of NF-kappaB, and this recent progress is covered in this review.
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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
Charles G. Mullighan,Salil Goorha,Ina Radtke,Christopher B. Miller,Elaine Coustan-Smith,James Dalton,Kevin Girtman,Susan Mathew,Jing Ma,Stanley Pounds,Xiaoping Su,Ching-Hon Pui,Mary V. Relling,William E. Evans,Sheila A. Shurtleff,James R. Downing +15 more
TL;DR: It is suggested that direct disruption of pathways controlling B-cell development and differentiation contributes to B-progenitor ALL pathogenesis and the power of high-resolution, genome-wide approaches to identify new molecular lesions in cancer.
Journal ArticleDOI
Regulation of plasma-cell development
TL;DR: This review focuses on the terminal differentiation of B cells into plasma cells, including the different subsets of B cell that become plasma cells), the mechanism of regulation of this transition, the transcription factors that control each developmental stage and the characteristics of long-lived plasma cells.
Journal ArticleDOI
Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates
Peter Laslo,Chauncey J. Spooner,Aryeh Warmflash,David W. Lancki,Hyun Jun Lee,Roger Sciammas,Benjamin N. Gantner,Aaron R. Dinner,Harinder Singh +8 more
TL;DR: It is demonstrated that at subthreshold levels, this Ets transcription factor regulates a mixed pattern (macrophage/neutrophil) of gene expression within individual myeloid progenitors, and assembled and mathematically model a gene regulatory network that exhibits both graded and bistable behaviors.
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