Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria Isabel D. Rossi,Antonio Carlos Carvalho,Hélio S. Dutra,Hans J.F. Dohmann,Guilherme V. Silva,Luciano Belem,Ricardo Vivacqua,Fernando Oswaldo Dias Rangel,Roberto Esporcatte,Yong-Jian Geng,William K. Vaughn,Joao A.R. Assad,Evandro Tinoco Mesquita,James T. Willerson +19 more
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TLDR
The present study demonstrates the relative safety of intramyocardial injections of bone marrow–derived stem cells in humans with severe heart failure and the potential for improving myocardial blood flow with associated enhancement of regional and global left ventricular function.Abstract:
Background— This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote neovascularization and improve perfusion and myocardial contractility. Methods and Results— Twenty-one patients were enrolled in this prospective, nonrandomized, open-label study (first 14 patients, treatment; last 7 patients, control). Baseline evaluations included complete clinical and laboratory evaluations, exercise stress (ramp treadmill), 2D Doppler echocardiogram, single-photon emission computed tomography perfusion scan, and 24-hour Holter monitoring. Bone marrow mononuclear cells were harvested, isolated, washed, and resuspended in saline for injection by NOGA catheter (15 injections of 0.2 cc). Electromechanical mapping was used to identify viable myocardium (unipolar voltage ≥6.9 mV) for treatment. Treated and control patients underwent 2-month noninvasive follow-up, and treated patients alone underwen...read more
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Somatic stem cell transplantation for the failing heart.
TL;DR: This review focuses on the SSC types currently indicated for cardiac regeneration and the methods for their surgical application into the failing heart.
Journal ArticleDOI
Intracoronary Autologous Bone Marrow−Derived Mononuclear Cell Transplantation Improves Coronary Collateral Vessel Formation and Recruitment Capacity in Patients With Ischemic Cardiomyopathy: A Combined Hemodynamic and Scintigraphic Approach
Yelda Tayyareci,Murat Sezer,Berrin Umman,Sevgi Kalayoglu Besisik,Ayse Mudun,Yasemin Sanli,Aytac Oncul,Nuray Gürses,Deniz Sargin,Mehmet Meriç,Yilmaz Nisanci +10 more
TL;DR: It is demonstrated for the first time (to the authors' knowledge) that intracoronary autologous BMC transplantation improves coronary collateral vessel formation and recruitment capacity in human subjects.
Journal Article
Validation of transcatheter left ventricular electromechanical mapping for assessment of cardiac function and targeted transendocardial injection in a porcine ischemia-reperfusion model
Sharven Taghavi,Jason M. Duran,Remus M. Berretta,Catherine A. Makarewich,Foram Udeshi,Thomas E. Sharp,Hajime Kubo,Steven R. Houser,Jon C. George +8 more
TL;DR: In a porcine model of ischemia-reperfusion injury, the use of the NOGA mapping system for assessment of cardiac function along with the Myostar injection catheter for directed delivery of therapeutics to localized target sites in the setting of acute myocardial injury is validated.
Patent
Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells
Kenneth R. Chien,Xiaojun Lian +1 more
TL;DR: In this paper, the authors used Jagged 1 and Frizzled 4 as cell surface markers for isolating human cardiomyogenic ventricular progenitor cells, in particular progenitors cells that preferentially differentiate into cardiac ventricular muscle cells.
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