Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria Isabel D. Rossi,Antonio Carlos Carvalho,Hélio S. Dutra,Hans J.F. Dohmann,Guilherme V. Silva,Luciano Belem,Ricardo Vivacqua,Fernando Oswaldo Dias Rangel,Roberto Esporcatte,Yong-Jian Geng,William K. Vaughn,Joao A.R. Assad,Evandro Tinoco Mesquita,James T. Willerson +19 more
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TLDR
The present study demonstrates the relative safety of intramyocardial injections of bone marrow–derived stem cells in humans with severe heart failure and the potential for improving myocardial blood flow with associated enhancement of regional and global left ventricular function.Abstract:
Background— This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote neovascularization and improve perfusion and myocardial contractility. Methods and Results— Twenty-one patients were enrolled in this prospective, nonrandomized, open-label study (first 14 patients, treatment; last 7 patients, control). Baseline evaluations included complete clinical and laboratory evaluations, exercise stress (ramp treadmill), 2D Doppler echocardiogram, single-photon emission computed tomography perfusion scan, and 24-hour Holter monitoring. Bone marrow mononuclear cells were harvested, isolated, washed, and resuspended in saline for injection by NOGA catheter (15 injections of 0.2 cc). Electromechanical mapping was used to identify viable myocardium (unipolar voltage ≥6.9 mV) for treatment. Treated and control patients underwent 2-month noninvasive follow-up, and treated patients alone underwen...read more
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Intramyocardial bone marrow cell transplantation and the progression of coronary atherosclerosis in patients with chronic myocardial ischemia
Saskia L.M.A. Beeres,Jeroen J. Bax,Stijntje D. Roes,Hildo J. Lamb,Willem E. Fibbe,Albert de Roos,Ernst E. van der Wall,Martin J. Schalij,Douwe E. Atsma +8 more
TL;DR: Intramyocardial bone marrow cell transplantation in patients with chronic myocardial ischemia was not associated with significant progression of atherosclerosis and there was no clinical evidence of progression of Atherosclerosis during the 12‐month follow-up period.
Journal ArticleDOI
The acute impact of high-dose lipid-lowering treatment on endothelial progenitor cells in patients with coronary artery disease-The REMEDY-EPC early substudy.
Rosalinda Madonna,Francesca Vera Renna,Paola Lanuti,Matteo Perfetti,Marco Marchisio,Carlo Briguori,Gerolama Condorelli,Lamberto Manzoli,Lamberto Manzoli,Raffaele De Caterina +9 more
TL;DR: No evidence of acute changes in levels or activity of EPCs and CECs after high-dose lipid-lowering therapy in stable CAD patients is found.
Journal ArticleDOI
Experimental models for cardiac regeneration.
Ana Sánchez,María Eugenia Fernández,Arancha Rodríguez,Jesús Fernández,Nuria Torre-Pérez,Juan M. Hurle,Javier García-Sancho +6 more
TL;DR: The results indicate that the damaged areas of human bone marrow cells express specific genes such as MPC1 and SDF1, and that some human BMCs migrate and graft near the lesion, where they can originate cells with a cardiac phenotype that produce human cardiac proteins.
Journal ArticleDOI
Correlation between endocardial voltage mapping and myocardial perfusion: implications for the assessment of myocardial ischemia.
Shmuel Fuchs,Ran Kornowski +1 more
TL;DR: Chronic myocardial ischemia, resulting in reduced perfusion and function at rest (that is, hibernating myocardium), is characterized by a significant reduction in endocardial UpV potentials, which correlates with reduced endomyocardial blood flow and tissue perfusion at rest.
Journal ArticleDOI
Prostacyclin improves transcoronary myocardial delivery of adipose tissue-derived stromal cells
TL;DR: PGI2 safely increases myocardial delivery of ADSCs, by mechanisms independent of its vasodilatory properties, with a potential for its use in cell therapy for cardiac repair.
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