Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria Isabel D. Rossi,Antonio Carlos Carvalho,Hélio S. Dutra,Hans J.F. Dohmann,Guilherme V. Silva,Luciano Belem,Ricardo Vivacqua,Fernando Oswaldo Dias Rangel,Roberto Esporcatte,Yong-Jian Geng,William K. Vaughn,Joao A.R. Assad,Evandro Tinoco Mesquita,James T. Willerson +19 more
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TLDR
The present study demonstrates the relative safety of intramyocardial injections of bone marrow–derived stem cells in humans with severe heart failure and the potential for improving myocardial blood flow with associated enhancement of regional and global left ventricular function.Abstract:
Background— This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote neovascularization and improve perfusion and myocardial contractility. Methods and Results— Twenty-one patients were enrolled in this prospective, nonrandomized, open-label study (first 14 patients, treatment; last 7 patients, control). Baseline evaluations included complete clinical and laboratory evaluations, exercise stress (ramp treadmill), 2D Doppler echocardiogram, single-photon emission computed tomography perfusion scan, and 24-hour Holter monitoring. Bone marrow mononuclear cells were harvested, isolated, washed, and resuspended in saline for injection by NOGA catheter (15 injections of 0.2 cc). Electromechanical mapping was used to identify viable myocardium (unipolar voltage ≥6.9 mV) for treatment. Treated and control patients underwent 2-month noninvasive follow-up, and treated patients alone underwen...read more
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Transplanted human cord blood-derived unrestricted somatic stem cells improve left-ventricular function and prevent left-ventricular dilation and scar formation after acute myocardial infarction
A Ghodsizad,M Niehaus,Gesine Kögler,Ulrich Martin,Peter Wernet,Christoph Bara,Nawid Khaladj,A Loos,M Makoui,J Thiele,Michael Mengel,Matthias Karck,HM Klein,Axel Haverich,Arjang Ruhparwar +14 more
TL;DR: Transplantation of USSCs significantly improved LV function and prevented scar formation as well as LV dilation in a porcine model of acute MI, and effectively preserved natural myocardial architecture.
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Regenerative capacity of the myocardium: implications for treatment of heart failure
TL;DR: A virtual case report of a patient with acute myocardial infarction is presented and treatment options are discussed, including strategies aimed at organ regeneration.
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Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies.
TL;DR: The critical safety issues associated with stem cell therapy are summarized, the outcomes of clinical stem cell trials are discussed, and the technical, ethical, and practical issues facing the clinical application of cardiac stem cells are identified.
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