Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells
Christophe Guilluy,Malvyne Rolli-Derkinderen,Pierre-Louis Tharaux,Gerry Melino,Pierre Pacaud,Gervaise Loirand +5 more
TLDR
Evidence is provided that 5-HT, internalized through the 5- HT transporter, is transamidated to RhoA by transglutaminase, which in turn is responsible for Akt activation and contraction inhibition in arterial smooth muscle.About:
This article is published in Journal of Biological Chemistry.The article was published on 2007-02-02 and is currently open access. It has received 109 citations till now. The article focuses on the topics: RHOA & Rho-associated protein kinase.read more
Citations
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Journal ArticleDOI
The Expanded Biology of Serotonin
TL;DR: New work suggests that serotonin may regulate some processes, including platelet aggregation, by receptor-independent, transglutaminase-dependent covalent linkage to cellular proteins.
Journal ArticleDOI
Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
Nils Paulmann,Maik Grohmann,Maik Grohmann,Jörg-Peter Voigt,Bettina Bert,Jakob Vowinckel,Jakob Vowinckel,Michael Bader,Maša Skelin,Marko Jevšek,Heidrun Fink,Marjan Slak Rupnik,Diego J. Walther +12 more
TL;DR: Non-neuronal, peripheral serotonin deficiency causes diabetes mellitus and an intracellular role for serotonin in the regulation of insulin secretion is identified.
Journal ArticleDOI
Transglutaminase Regulation of Cell Function
Richard L. Eckert,Mari T. Kaartinen,Maria Nurminskaya,Alexey M. Belkin,Gozde Colak,Gail V.W. Johnson,Kapil Mehta +6 more
TL;DR: The studies described herein begin to clarify the physiological roles of TGs in both normal biology and disease states and highlight the mechanism of action of these proteins with respect to their structure, impact on cell differentiation and survival, role in cancer development and progression.
Book ChapterDOI
Cellular functions of tissue transglutaminase.
TL;DR: The complex biochemical activities and molecular interactions of TG2 are discussed in the context of diverse subcellular compartments and its wide ranging and cell type-specific biological functions and their regulation are evaluated.
Journal ArticleDOI
Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension.
TL;DR: Observations indicate that independent of the cause of PH, activation of the RhoA/ROCK pathway serves as a point of convergence of various signalling cascades in the pathogenesis of the disease.
References
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Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton
TL;DR: The results show that ECM, cytoskeletal structures and soluble factors all contribute to regulation of Rho activity, and both cytochalasin D and colchicine trigger Rho activation despite their opposite effects on stress fibers and focal adhesions.
Journal ArticleDOI
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.
Yasuko Kureishi,Zhengyu Luo,Ichiro Shiojima,Ann Bialik,David Fulton,David J. Lefer,William C. Sessa,Kenneth Walsh +7 more
TL;DR: Simvastatin enhanced phosphorylation of the endogenous Akt substrate endothelial nitric oxide synthase, inhibited apoptosis and accelerated vascular structure formation in vitro in an Akt-dependent manner, and promoted angiogenesis in ischemic limbs of normocholesterolemic rabbits.
Journal ArticleDOI
Transglutaminases: crosslinking enzymes with pleiotropic functions
Laszlo Lorand,Robert M. Graham +1 more
TL;DR: Having knowledge of transglutaminases is essential for understanding the aetiologies of diverse hereditary diseases of the blood and skin, and various autoimmune, inflammatory and degenerative conditions.
Journal ArticleDOI
Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase
Ulrich Laufs,James K. Liao +1 more
TL;DR: Findings indicate that Rho negatively regulates eNOS expression and that HMG-CoA reductase inhibitors up-regulate eN OS expression by blocking Rho geranylgeranylation, which is necessary for its membrane-associated activity.