Journal ArticleDOI
Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers
William I. Bensinger,Paul J. Martin,Barry E. Storer,Reginald A. Clift,Steven J. Forman,Robert S. Negrin,Ashwin Kashyap,Mary E.D. Flowers,K Lilleby,Thomas R. Chauncey,Rainer Storb,Frederick R. Appelbaum +11 more
TLDR
In patients given high-dose chemotherapy, with or without radiation, for the treatment of hematologic cancer,allogeneic peripheral-blood cells used for hematopoietic rescue restore blood counts faster than allogeneic bone marrow, without increasing the risk of graft-versus-host disease.Abstract:
Background In recipients of allogeneic hematopoietic-cell transplants, peripheral-blood cells mobilized with the use of filgrastim (recombinant granulocyte colony-stimulating factor) engraft more rapidly than bone marrow. However, the relative effects of these techniques on the rates of acute and chronic graft-versus-host disease, overall survival, and disease-free survival have not been determined in randomized studies. Methods Between March 1996 and July 1999, 172 patients (12 to 55 years of age) with hematologic cancer were randomly assigned to receive either bone marrow or filgrastim-mobilized peripheral-blood cells from HLA-identical relatives for hematopoietic rescue after the treatment of hematologic cancer with high doses of chemotherapy, with or without radiation. Results The recovery of both neutrophils and platelets was faster with peripheral-blood cells than with marrow (P<0.001 for both comparisons). The cumulative incidence of grade II, III, or IV acute graft-versus-host disease at 100 days ...read more
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Journal ArticleDOI
Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
TL;DR: Risk factor analyses verify previously recognized risk factors (GVHD, receipt of corticosteroids, and neutropenia) and uncover the roles of lymphopenia and viral infections in increasing the incidence of postengraftment IA in the 1990s.
Journal ArticleDOI
Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
Hillard M. Lazarus,Omer N. Koc,Steven M. Devine,Peter T. Curtin,Richard T. Maziarz,H. Kent Holland,Elizabeth J. Shpall,Philip L. McCarthy,Kerry Atkinson,Brenda W. Cooper,Stanton L. Gerson,Mary J. Laughlin,Fausto R. Loberiza,Annemarie Moseley,Andrea Bacigalupo +14 more
TL;DR: Cotransplantation of HLA-identical sibling culture-expanded MSCs with an HLA and hematopoietic HSC transplant is feasible and seems to be safe, without immediate infusional or late MSC-associated toxicities.
Journal ArticleDOI
Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells.
Martin Korbling,Ruth L. Katz,Abha Khanna,Arnout C.C. Ruifrok,Gabriela Rondon,Maher Albitar,Richard E. Champlin,Zeev Estrov +7 more
TL;DR: All six recipients of sex-mismatched transplants showed evidence of complete hematopoietic donor chimerism and the presence of donor cells in the biopsy specimens did not seem to depend on the intensity of tissue damage induced by graft-versus-host disease.
Journal ArticleDOI
Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors
Claudio Anasetti,Brent R. Logan,Stephanie J. Lee,Edmund K. Waller,Daniel J. Weisdorf,John R. Wingard,Corey Cutler,Peter Westervelt,Ann E. Woolfrey,Stephen Couban,Gerhard Ehninger,Laura Johnston,Richard T. Maziarz,Michael A. Pulsipher,David L. Porter,Shin Mineishi,John M. McCarty,Shakila P. Khan,Paolo Anderlini,William I. Bensinger,Susan F. Leitman,Scott D. Rowley,Christopher Bredeson,Shelly L. Carter,Mary M. Horowitz,Dennis L. Confer +25 more
TL;DR: A phase 3, multicenter, randomized trial of transplantation of peripheral-blood stem cells versus bone marrow from unrelated donors did not detect significant survival differences, and exploratory analyses of secondary end points indicated that peripheral- Blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduceThe risk of chronic GVHD.
Journal ArticleDOI
Cyclophosphamide and cancer: golden anniversary.
TL;DR: The chemistry, pharmacology, clinical toxic effects and current clinical applications of cyclophosphamide in cancer and autoimmune disorders, and the development of high-dose cycloph phosphamide for BMT and the treatment of autoimmune diseases are discussed.
References
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