Journal ArticleDOI
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives.
Antonio Grimaldi,Ana Olga Mocumbi,Juergen Freers,Matthias Lachaud,Mariana Mirabel,Beatriz Ferreira,Kumar Narayanan,David S. Celermajer,Daniel Sidi,Xavier Jouven,Eloi Marijon +10 more
TLDR
Tropical endomyocardial fibrosis is a neglected disease of poverty that afflicts rural populations in tropical low-income countries, with some certain high-prevalence areas with a very poor prognosis.Abstract:
Tropical endomyocardial fibrosis (EMF) is a neglected disease of poverty that afflicts rural populations in tropical low-income countries, with some certain high-prevalence areas. Tropical EMF is characterized by the deposition of fibrous tissue in the endomyocardium, leading to restrictive physiology. Since the first descriptions in Uganda in 1948, high-frequency areas for EMF have included Africa, Asia, and South America. Although there is no clear consensus on a unified hypothesis, it seems likely that dietary, environmental, and infectious factors may combine in a susceptible individual to give rise to an inflammatory process leading to endomyocardial damage and scar formation. The natural history of EMF includes an active phase with recurrent flare-ups of inflammation evolving to a chronic phase leading to restrictive heart failure. In the chronic phase, biventricular involvement is the most common presentation, followed by isolated right-sided heart disease. Marked ascites out of proportion to peripheral edema usually develops as a typical feature of EMF. EMF carries a very poor prognosis. In addition to medical management of heart failure, early open heart surgery (endocardectomy and valve repair/replacement) appears to improve outcomes to some extent; however, surgery is technically challenging and not available in most endemic areas. Increased awareness among health workers and policy makers is the need of the hour for the unhindered development of efficient preventive and therapeutic strategies.read more
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How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Burkert Pieske,Carsten Tschöpe,Rudolf A. de Boer,Alan G. Fraser,Stefan D. Anker,Erwan Donal,Frank Edelmann,Michael Fu,Marco Guazzi,Carolyn S.P. Lam,Patrizio Lancellotti,Vojtech Melenovsky,Daniel A. Morris,Eike Nagel,Elisabeth Pieske-Kraigher,Piotr Ponikowski,Scott D. Solomon,Ramachandran S. Vasan,Frans H. Rutten,Adriaan A. Voors,Frank Ruschitzka,Walter Paulus,Petar M. Seferovic,Gerasimos Filippatos,Gerasimos Filippatos +24 more
TL;DR: A new stepwise diagnostic process, the 'HFA-PEFF diagnostic algorithm', is recommended, which requires comprehensive echocardiography and requires comprehensive natriuretic peptide levels and is typically performed by a cardiologist.
Journal ArticleDOI
Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.
Petar M. Seferovic,Petar M. Seferovic,Marija Polovina,Johann Bauersachs,Michael Arad,Tuvia Ben Gal,Lars Lund,Stephan B. Felix,Eloisa Arbustini,Alida L.P. Caforio,Dimitrios Farmakis,Gerasimos Filippatos,Elias Gialafos,Vladimir Kanjuh,Gordana Krljanac,Giuseppe Limongelli,Aleš Linhart,Alexander R. Lyon,Ružica Maksimović,Davor Milicic,Ivan Milinković,Michel Noutsias,Ali Oto,Öztekin Oto,Sinisa U. Pavlovic,Massimo F Piepoli,Arsen D. Ristić,Giuseppe M.C. Rosano,Hubert Seggewiss,Milika Asanin,Jelena P. Seferovic,Jelena P. Seferovic,Frank Ruschitzka,Jelena Celutkiene,Tiny Jaarsma,Christian Mueller,Brenda Moura,Loreena Hill,Maurizio Volterrani,Yuri Lopatin,Marco Metra,Johannes Backs,Wilfried Mullens,Ovidiu Chioncel,Rudolf A. de Boer,Stefan D. Anker,Claudio Rapezzi,Andrew J.S. Coats,Andrew J.S. Coats,Carsten Tschöpe +49 more
TL;DR: E epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies are focused on.
Journal ArticleDOI
Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective
TL;DR: The burden of non-communicable diseases including cardiovascular diseases is rising in SSA, with ischemic heart disease accounting for <10% of cases compared to >50% in high-income countries, while contrasting with the HIC and highlighting impediments to their management and making recommendations.
Journal ArticleDOI
Cardiomyopathies: An Overview.
TL;DR: In this compendium, some of the most important advances in this field are reviewed and scientific opportunities to enhance further collaborative research to accelerate progress are identified.
Journal ArticleDOI
Cardiac manifestations of parasitic diseases.
Maria do Carmo Pereira Nunes,Milton Henriques Guimaraes Junior,Adriana C. Diamantino,Cláudio Léo Gelape,Teresa C. A. Ferrari +4 more
TL;DR: Current knowledge on the major heart diseases caused by protozoan and metazoan parasites, which either involve the heart directly or otherwise influence the heart adversely, is updated and summarised.
References
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Journal ArticleDOI
The Causes, Treatment, and Outcome of Acute Heart Failure in 1006 Africans From 9 Countries Results of the Sub-Saharan Africa Survey of Heart Failure
Albertino Damasceno,Bongani M. Mayosi,Mahmoud U Sani,Okechukwu S Ogah,Charles Mondo,Dike B. Ojji,Anastase Dzudie,Charles Kouam Kouam,Ahmed Suliman,Neshaad Schrueder,Gerald Yonga,Serigne Abdou Ba,Fikru Maru,Bekele Alemayehu,Christopher L. Edwards,Beth A. Davison,Gad Cotter,Karen Sliwa +17 more
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Journal ArticleDOI
Cassava cyanogens and konzo, an upper motoneuron disease found in Africa.
TL;DR: Findings indicate a causal role in konzo of sustained high blood cyanide concentrations maintained by a deficient sulphur intake impairing cyanide to thiocyanate conversion, but a minor improvement of food processing may, as in beri-beri, be preventive.
Journal ArticleDOI
Epidemiology and etiology of cardiomyopathy in Africa
TL;DR: There is a need for large-scale epidemiological studies of the incidence, prevalence, determinants, and outcome of cardiomyopathy in Africa to inform strategies for the treatment and prevention of heart muscle disease on the continent.