Journal ArticleDOI
Tumor Microenvironment-Activated Ultrasensitive Nanoprobes for Specific Detection of Intratumoral Glutathione by Ratiometric Photoacoustic Imaging
Longguang Tang,Fei Yu,Bowen Tang,Zhen Yang,Wenpei Fan,Mingru Zhang,Zhantong Wang,Orit Jacobson,Zijian Zhou,Ling Li,Yijing Liu,Dale O. Kiesewetter,Wei Tang,Liangcan He,Ying Ma,Gang Niu,Xianzhong Zhang,Xiaoyuan Chen +17 more
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TLDR
A novel intelligent tumor microenvironment-activated ratiometric PAI nanoprobe is developed with the intention of specific ultrasensitive detection of intratumoral GSH by overcoming the limitations of previously reported fluorescent or PA imaging sensors.Abstract:
Glutathione (GSH), one of the most significant reducing species in vivo, plays important roles in a variety of diseases and cellular functions. Precise quantification of GSH via advanced noninvasive photoacoustic imaging (PAI) is of vital significance for the early diagnosis and prompt treatment of GSH-related deep-seated diseases, which stresses the need for custom-design of GSH-sensitive PAI probes with changeable near-infrared spectroscopy (NIR) absorption. In this work, a novel intelligent tumor microenvironment-activated ratiometric PAI nanoprobe is first developed with the intention of specific ultrasensitive detection of intratumoral GSH by overcoming the limitations of previously reported fluorescent or PA imaging sensors. This special ratiometric PAI nanoprobe (CR-POM) is synthesized through the self-assembly of croconaine (CR) dye and molybdenum-based polyoxometalate (POM) clusters with opposite NIR absorbance change in response to GSH. The resulting amplified ratiometric absorbance (Ab866/Ab700), the relatively low limit of detection value (0.51 mM), and the unique acidity-activated self-aggregation contribute to the prolonged intratumoral retention and enhanced tumor accumulation of CR-POM for accurate quantification of intratumoral GSH (0.5-10 mM). Featuring the additional merit of 64Cu radiolabeling for whole-body positron-emission tomography imaging, the smartly designed CR-POM nanoprobe will open new horizons for real-time noninvasive monitoring of biodistribution and simultaneous accurate quantification of GSH levels, especially in tumor and other GSH-related pathophysiological processes.read more
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Recent progress in the development of fluorescent probes for detection of biothiols
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Fluorescent-based nanosensors for selective detection of a wide range of biological macromolecules: A comprehensive review.
Saman Sargazi,Iqra Fatima,Maria Hassan Kiani,Vahideh Mohammadzadeh,Rabia Arshad,Muhammad Bilal,Abbas Rahdar,Ana M. Díez-Pascual,Razieh Behzadmehr +8 more
TL;DR: In this paper , the authors comprehensively overviewed the electrochemical sensors that employ nanomaterials (nanoparticles/colloids or quantum dots, carbon dots, or nanoscaled metal-organic frameworks, etc.) to detect a variety of biological macromolecules based on fluorescent emission spectra.
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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications.
Yongchao Liu,Lili Teng,Baoli Yin,Hong-Min Meng,Xia Yin,Shuangyan Huan,Guosheng Song,Xiao-Bing Zhang +7 more
TL;DR: In this article , a review of the recent developments of activatable photoacoustic (PA) probes for precise biomedical applications including molecular detection of the biotargets and imaging of the biological events is presented.
Journal ArticleDOI
Colorimetric and fluorescent detection of glutathione over cysteine and homocysteine with red-emitting N-doped carbon dots
TL;DR: Red-emitting carbon dots prepared by a simple one-step solvothermal process can exclusively, rapidly and sensitively respond to GSH owing to the high content of pyridinic N, and offers a great opportunity to accurately, sensitively and selectively detect GSH by colorimetric and fluorescent dual modes.
Journal ArticleDOI
Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy.
Xiaoting Gao,Shanshan Jiang,Chunying Li,Yunzhi Chen,Yifan Zhang,Peng Huang,Jing Lin,Jing Lin +7 more
TL;DR: Highly photostable amphiphilic croconium dye-anchored red blood cell membrane vesicle is developed for tumor pH-responsive near-infrared fluorescence (NIRF) and photoacoustic (PA) duplex imaging-guided photothermal therapy for cancer theranostics.
References
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Lihong V. Wang,Song Hu +1 more
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Journal ArticleDOI
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Kanyi Pu,Adam J. Shuhendler,Jesse V. Jokerst,Jianguo Mei,Sanjiv S. Gambhir,Zhenan Bao,Jianghong Rao +6 more
TL;DR: Near infrared (NIR) light absorbing semiconducting polymer nanoparticles (SPNs) are introduced as a new class of contrast agents for PA molecular imaging and demonstrate SPNs an ideal nanoplatform for developing PA molecular probes.
Journal ArticleDOI
CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
Takatsugu Ishimoto,Osamu Nagano,Toshifumi Yae,Mayumi Tamada,Takeshi Motohara,Hiroko Oshima,Masanobu Oshima,Tatsuya Ikeda,Rika Asaba,Hideki Yagi,Takashi Masuko,Takatsune Shimizu,Tomoki Ishikawa,Tomoki Ishikawa,Kazuharu Kai,Eri Takahashi,Yu Imamura,Yoshifumi Baba,Mitsuyo Ohmura,Makoto Suematsu,Hideo Baba,Hideyuki Saya +21 more
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