Tumor targeting using liposomal antineoplastic drugs.
TLDR
The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.Abstract:
During the last years, liposomes (microparticulate phospholipid vesicles) have been used with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumor drugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.read more
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Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.
TL;DR: In this review, state-of-the-art nanoparticles and targeted systems that have been investigated in clinical studies are discussed and the challenges faced in using nanomedicine products and translating them from a preclinical level to the clinical setting are emphasized.
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Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.
TL;DR: This review offers a detailed description of different cytotoxic drug carriers, such as liposomes, carbon nanotubes, dendrimers, polymeric micelles,polymeric conjugates and polymeric nanoparticles, in passive and active targeted cancer therapy, by enhancing the permeability and retention or by the functionalization of the surface of the carriers.
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Current trends in the use of liposomes for tumor targeting
TL;DR: A review of the recent advances in liposome research in tumor targeting discusses the development of multifunctional liposomes that target cells and cellular organelles with a single delivery system.
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Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects.
TL;DR: Transferrin-PEG-liposomes improve the safety and efficacy of anti cancer drug by both passive targeting by prolonged circulation and active targeting by transferrin.
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Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity
TL;DR: In vitro and in vivo studies prove that the synergistic effects of GSNs for the efficacious treatment of hepatocellular carcinomas are better than the chemotherapy or photothermal therapy alone.
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Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.
Peter McLaughlin,Antonio J. Grillo-Lopez,Brian K. Link,Ronald Levy,Myron S. Czuczman,Michael E. Williams,M R Heyman,I. Bence-Bruckler,Christine A. White,Fernando Cabanillas,Vinay K. Jain,A D Ho,John Lister,K Wey,D. Shen,Brian Dallaire +15 more
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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
Franz Thiebaut,Takashi Tsuruo,Hirofumi Hamada,Michael M. Gottesman,Ira Pastan,Mark C. Willingham +5 more
TL;DR: The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract.
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