Twins Early Development Study (TEDS): a genetically sensitive investigation of cognitive and behavioral development from childhood to young adulthood.
TLDR
The Twins Early Development Study (TEDS) is a large longitudinal sample of twins born in England and Wales between 1994 and 1996 that represents an outstanding resource for investigating the developmental effects of genes and environments on complex quantitative traits from childhood to young adulthood and beyond.Abstract:
The Twins Early Development Study (TEDS) is a large longitudinal sample of twins born in England and Wales between 1994 and 1996. The focus of TEDS has been on cognitive and behavioral development, including difficulties in the context of normal development. TEDS began when multiple births were identified from birth records and the families were invited to take part in the study; 16,810 pairs of twins were originally enrolled in TEDS. More than 10,000 of these twin pairs remain enrolled in the study to date. DNA has been collected for more than 7,000 pairs, and genome-wide genotyping data for two million DNA markers are available for 3,500 individuals. The TEDS families have taken part in studies when the twins were aged 2, 3, 4, 7, 8, 9, 10, 12, 14, and 16 years of age. Data collection is currently underway to assess the adult destinations of the twins as they move from school to university and the workplace. Between January 2012 and December 2014, all of the TEDS twins will turn 18, and the study will transition to an adult sample. TEDS represents an outstanding resource for investigating the developmental effects of genes and environments on complex quantitative traits from childhood to young adulthood and beyond.read more
Citations
More filters
Journal ArticleDOI
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Antonio F. Pardiñas,Peter Holmans,Andrew Pocklington,Valentina Escott-Price,Stephan Ripke,Stephan Ripke,Noa Carrera,Sophie E. Legge,Sophie Bishop,D. F. Cameron,Marian L. Hamshere,Jun Han,Leon Hubbard,Amy Lynham,Kiran Kumar Mantripragada,Elliott Rees,James H. MacCabe,Steven A. McCarroll,Bernhard T. Baune,Gerome Breen,Gerome Breen,Enda M. Byrne,Udo Dannlowski,Thalia C. Eley,Caroline Hayward,Nicholas G. Martin,Nicholas G. Martin,Andrew M. McIntosh,Robert Plomin,David J. Porteous,Naomi R. Wray,Armando Caballero,Daniel H. Geschwind,Laura M. Huckins,Douglas M. Ruderfer,Enrique Santiago,Pamela Sklar,Eli A. Stahl,Hyejung Won,Esben Agerbo,Esben Agerbo,Thomas Damm Als,Thomas Damm Als,Ole A. Andreassen,Ole A. Andreassen,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Preben Bo Mortensen,Preben Bo Mortensen,Carsten Bøcker Pedersen,Carsten Bøcker Pedersen,Anders D. Børglum,Anders D. Børglum,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Srdjan Djurovic,Srdjan Djurovic,Naser Durmishi,Marianne Giørtz Pedersen,Marianne Giørtz Pedersen,Vera Golimbet,Jakob Grove,David M. Hougaard,David M. Hougaard,Manuel Mattheisen,Manuel Mattheisen,Espen Molden,Ole Mors,Ole Mors,Merete Nordentoft,Merete Nordentoft,Milica Pejovic-Milovancevic,Engilbert Sigurdsson,Teimuraz Silagadze,Christine Søholm Hansen,Christine Søholm Hansen,Kari Stefansson,Hreinn Stefansson,Stacy Steinberg,Sarah Tosato,Thomas Werge,Thomas Werge,Thomas Werge,David A. Collier,David A. Collier,Dan Rujescu,Dan Rujescu,George Kirov,Michael J. Owen,Michael Conlon O'Donovan,James T.R. Walters +90 more
TL;DR: A new genome-wide association study of schizophrenia is reported, and through meta-analysis with existing data and integrating genomic fine-mapping with brain expression and chromosome conformation data, 50 novel associated loci and 145 loci are identified.
Journal ArticleDOI
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
TL;DR: Evidence from pediatric samples around the world indicates that these traits are associated with body mass index, are heritable, and are linked to polymorphisms in the FTO gene, also discussing their relevance to practical issues of parental feeding styles, portion sizes, and health literacy and numeracy.
Journal ArticleDOI
Heritability of autism spectrum disorders: a meta‐analysis of twin studies
TL;DR: It is demonstrated that ASD is due to strong genetic effects and shared environmental effects become significant as a function of lower prevalence rate, and previously reported significant shared environmental influences are likely a statistical artefact of overinclusion of concordant DZ twins.
Journal ArticleDOI
Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample
Emma Colvert,Beata Tick,Fiona McEwen,Catherine Stewart,Catherine Stewart,Sarah Curran,Sarah Curran,Sarah Curran,Emma Woodhouse,Nicola Gillan,Victoria Hallett,Stephanie Lietz,Tracy Garnett,Angelica Ronald,Angelica Ronald,Robert Plomin,Fruhling Rijsdijk,Francesca Happé,Patrick Bolton,Patrick Bolton +19 more
TL;DR: The liability to ASD and a more broadly defined high-level autism trait phenotype in this large population-based twin sample derives primarily from additive genetic and, to a lesser extent, nonshared environmental effects.
Journal ArticleDOI
Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
Chloe C. Y. Wong,Emma L. Meaburn,Angelica Ronald,Thomas S. Price,Aaron R. Jeffries,Leonard C. Schalkwyk,Robert Plomin,Jonathan Mill +7 more
TL;DR: This study represents the first systematic epigenomic analyses of MZ twins discordant for ASD and implicates a role for altered DNA methylation in autism.
References
More filters
Journal ArticleDOI
Evidence for substantial genetic risk for psychopathy in 7-year-olds.
TL;DR: The remarkably high heritability for CU, and for AB children with CU, suggests that molecular genetic research on antisocial behaviour should focus on the CU core of psychopathy, and raises questions for public policy on interventions for antissocial behaviour.
Journal ArticleDOI
Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment
TL;DR: Genetic influences on BMI and abdominal adiposity are high in children born since the onset of the pediatric obesity epidemic, and most of the genetic effect on abdomen adiposity is common to BMI, but 40% is attributable to independent genetic influences.
Journal ArticleDOI
Genetic Heterogeneity Between the Three Components of the Autism Spectrum: A Twin Study
Angelica Ronald,Francesca Happé,Patrick Bolton,Lee M. Butcher,Thomas S. Price,Sally Wheelwright,Simon Baron-Cohen,Robert Plomin +7 more
TL;DR: The results suggest the triad of impairments that define autism spectrum disorders is heterogeneous genetically, and molecular genetic research examining the three aspects separately may identify different causal pathways for the three components.
Journal ArticleDOI
Twins Early Development Study (TEDS): A Multivariate, Longitudinal Genetic Investigation of Language, Cognition and Behavior Problems in Childhood
TL;DR: A result that suggests that general impairment may be a better target for genetic research than specific language impairment independent of nonverbal cognitive problems is found, and DNA has been obtained so far for more than 4000 pairs is being used initially in molecular genetic studies of language problems and hyperactivity.
Journal ArticleDOI
Infant zygosity can be assigned by parental report questionnaire data
Thomas S. Price,Bernard Freeman,Ian W. Craig,Stephen A. Petrill,Lorna Ebersole,Robert Plomin +5 more
TL;DR: A parental report questionnaire posted to a population sample of 18-month-old twins correctly assigned zygosity in 95% of cases when validated against zygosa determined by identity of polymorphic DNA markers.