Journal ArticleDOI
Unraveling the crystal structure of Leptospira kmetyi riboflavin synthase and computational analyses for potential development of new antibacterials
Sayangku Nor Ariati Mohamad Aris,Raja Noor Zaliha Raja Abdul Rahman,Mohd Shukuri Mohamad Ali,Mohd Anuar Jonet,Taiki Motomura,Noor Dina Muhd Noor,Fairolniza Mohd Shariff,Kai Cheng Hsu,Leow Thean Chor +8 more
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TLDR
In this article , the crystal structure of riboflavin synthase from leptospira kmetyi was determined at 3.2 Å and belonged to the orthorhombic space group P212121, with an R-factor of 21.8%.About:
This article is published in Journal of Molecular Structure.The article was published on 2022-06-01. It has received 2 citations till now. The article focuses on the topics: Chemistry & Orthorhombic crystal system.read more
Citations
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Therapeutic Target Identification and Inhibitor Screening against Riboflavin Synthase of Colorectal Cancer Associated Fusobacterium nucleatum
Norah A. Alturki,Mutaib M Mashraqi,Khurshid Jalal,Kanwal Waseem Khan,Zarrin Basharat,Ahmad A. Alzamami +5 more
TL;DR: In this paper , the authors identified 538 proteins as essential for Fusobacterium nucleatum survival, 209 nonhomologous to a human host, and 12 as drug targets.
Journal ArticleDOI
Subtractive sequence-mediated therapeutic targets from the conserved gene clusters of Campylobacter hyointestinalis and computational inhibition assessment.
Zarrin Basharat,Y. S. Alghamdi,Mutaib M Mashraqi,Mohammed A. Makkawi,Sultan Alasmari,Saleh Alshamrani +5 more
TL;DR: Sarma et al. as discussed by the authors used subtractive computational screening of the C. hyointestinalis genome for the purpose of identifying the therapeutic targets and reported no therapeutic targets have been identified and reported in this bacterium.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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UCSF Chimera--a visualization system for exploratory research and analysis.
Eric F. Pettersen,Thomas D. Goddard,Conrad C. Huang,Gregory S. Couch,Daniel M. Greenblatt,Elaine C. Meng,Thomas E. Ferrin +6 more
TL;DR: Two unusual extensions are presented: Multiscale, which adds the ability to visualize large‐scale molecular assemblies such as viral coats, and Collaboratory, which allows researchers to share a Chimera session interactively despite being at separate locales.
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Coot: model-building tools for molecular graphics.
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Journal ArticleDOI
Solvent content of protein crystals.
TL;DR: An analysis of the solvent content of 116 different crystal forms of globular proteins found that in many cases this range will be sufficiently restrictive to enable the probable number of molecules in the crystallographic asymmetric unit to be determined directly from the molecular weight of the protein and the space group and unit cell dimensions of the crystal.
Journal ArticleDOI
REFMAC5 for the refinement of macromolecular crystal structures
Garib N. Murshudov,Pavol Skubák,Andrey Lebedev,Navraj S. Pannu,Roberto A. Steiner,Robert A. Nicholls,Winn,Fei Long,Alexei A. Vagin +8 more
TL;DR: The general principles behind the macromolecular crystal structure refinement program REFMAC5 are described.