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Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis

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TLDR
Evidence suggests that high midlife TC increases risk of late-life AD, and may correlate with the onset of AD pathology, and significant gaps in the literature regarding TC and late- life dementia remain.
Abstract
This work was supported by NHMRC Research Fellowship #1002560 for KJA, and NIHR fellowship PDF-2012-05-197 for RP.

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2022 Alzheimer's disease facts and figures

Anonymous
TL;DR: The public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society are described are described.
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Contribution of alcohol use disorders to the burden of dementia in France 2008-13: a nationwide retrospective cohort study

TL;DR: Alcohol use disorders were a major risk factor for onset of all types of dementia, and especially early-onset dementia, so screening for heavy drinking should be part of regular medical care, with intervention or treatment being offered when necessary.
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Physical Activity and Sports-Real Health Benefits: A Review with Insight into the Public Health of Sweden

TL;DR: In conclusion, sports can be evolving, if personal capacities, social situation, and biological and psychological maturation are taken into account and evidence suggests a dose–response relationship such that being active, even to a modest level, is superior to being inactive or sedentary.
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The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms.

TL;DR: A narrative review aims to explain why there is still controversy over statin use and how both effects can, and may, be possible.
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Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment.

TL;DR: A broad perspective is given on the relationship between hypercholesterolemia and AD, cholesterol lowering therapies for AD patients and the role of oxysterols in pathological and non-pathological conditions, and proposes cholesterol metabolites as valuable targets for prevention and alternative AD treatments.
References
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Journal ArticleDOI

Meta-Analysis in Clinical Trials*

TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Quantifying heterogeneity in a meta‐analysis

TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
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Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

TL;DR: A reporting guideline is described, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015), which consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review.
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