Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function
Michael J. Parsons,Christina Grimm,Jose L. Paya-Cano,Karen Sugden,Wilfried Nietfeld,Hans Lehrach,Leonard C. Schalkwyk +6 more
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TLDR
An in silico correlation analysis of the expression of these differentially expressed miRNAs with phenotype data and mRNA expression was conducted to better characterise the effects of these mi RNAs on both phenotype and the regulation of mRNA expression.Abstract:
Micro-RNAs (miRNAs) are short, single-stranded, noncoding RNAs that are involved in the regulation of protein-coding genes at the level of messenger RNA (mRNA). They are involved in the regulation of numerous traits, including developmental timing, apoptosis, immune function, and neuronal development. To better understand how the expression of the miRNAs themselves is regulated, we looked for miRNA expression differences among four mouse inbred strains, A/J, BALB/cJ, C57BL/6J, and DBA/2J, in one tissue, the hippocampus. A total of 166 miRNA RT-PCR assays were used to screen RNA pools for each strain. Twenty miRNA species that were markedly different between strains were further investigated using eight individual samples per strain, and 11 miRNAs showed significant differences across strains (p < 0.05). This is the first observation of miRNA expression differences across inbred mice strains. We conducted an in silico correlation analysis of the expression of these differentially expressed miRNAs with phenotype data and mRNA expression to better characterise the effects of these miRNAs on both phenotype and the regulation of mRNA expression. This approach has allowed us to nominate miRNAs that have potential roles in anxiety, exploration, and learning and memory.read more
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microRNA‐34c is a novel target to treat dementias
Athanasios Zovoilis,Hope Y Agbemenyah,Roberto Carlos Agis-Balboa,Roman M. Stilling,Dieter Edbauer,Pooja Rao,Laurent Farinelli,Ivana Delalle,Andrea Schmitt,Andrea Schmitt,Peter Falkai,Peter Falkai,Sanaz Bahari-Javan,Susanne Burkhardt,Farahnaz Sananbenesi,Andre Fischer,Andre Fischer +16 more
TL;DR: The data suggest that miR‐34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34ccould be a suitable therapy.
Journal ArticleDOI
MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34
Sharon Haramati,Inbal Livni Navon,Orna Issler,Gili Ezra-Nevo,Shosh Gil,Raaya Zwang,Eran Hornstein,Alon Chen +7 more
TL;DR: A physiological role for microRNAs in regulating the central stress response is suggested and they are position them as potential targets for treatment of stress-related disorders.
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MicroRNA networks direct neuronal development and plasticity
N.F.M. Olde Loohuis,Aron Kos,Gerard J.M. Martens,H Van Bokhoven,Nael Nadif Kasri,Armaz Aschrafi +5 more
TL;DR: An overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation is provided.
Journal ArticleDOI
Big effects of small RNAs: A review of microRNAs in Anxiety
TL;DR: The involvement of miRNAs in CNS functions and their intricate regulatory role under stressful conditions strongly support their importance in the aetiology of anxiety disorders and could provide new avenues for the development of therapeutic targets in anxiety disorders.
Journal ArticleDOI
The Role of microRNAs in Alzheimer's Disease and Their Therapeutic Potentials.
Munvar Miya Shaik,Ian A. Tamargo,Murtala Bello Abubakar,Mohammad Amjad Kamal,Nigel H. Greig,Siew Hua Gan +5 more
TL;DR: Comprehensive understandings of the expression profiles and activities of these miRNAs will illuminate their roles as potential therapeutic targets in AD brain and may lead to the discovery of breakthrough treatment strategies for AD.
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