Journal ArticleDOI
Vaccines and Disease-Modifying Antirheumatic Drugs: Practical Implications for the Rheumatologist.
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TLDR
"This work reviews the available data regarding the impact of rheumatoid arthritis therapy on the immunogenicity of various common vaccines, and also reviews rheumatic arthritis-specific vaccination recommendations, live vaccine safety concerns, and current gaps in understanding of these issues.Abstract:
Patients with rheumatoid arthritis are highly vulnerable to infections because of abnormalities in their immune system, and because of immunosuppressive effects of their medications. Vaccinations in this population are complicated by disease-modifying antirheumatic drugs, which also modulate or suppress the immune system and potentially decrease the immunogenicity and efficacy of the vaccines. We review the available data regarding the impact of rheumatoid arthritis therapy on the immunogenicity of various common vaccines. We also review rheumatoid arthritis-specific vaccination recommendations, live vaccine safety concerns, and current gaps in our understanding of these issues."read more
Citations
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Journal ArticleDOI
Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus.
Ayelet Grupper,Liane Rabinowich,Doron Schwartz,Idit F. Schwartz,Merav Ben-Yehoyada,Moshe Shashar,Moshe Shashar,Eugene Katchman,Tami Halperin,Dan Turner,Yaacov Goykhman,Oren Shibolet,Sharon Levy,Inbal Houri,Roni Baruch,Helena Katchman +15 more
TL;DR: In this paper, the authors analyzed the humoral response following full vaccination with the BNT162b2 (Pfizer-BioNTech) in 136 kidney transplant recipients, and compared it to 25 controls.
Journal ArticleDOI
B-cell Therapy for Multiple Sclerosis: Entering an era.
TL;DR: The nuanced roles of B cells in MS autoimmunity, the clinical data supporting use of ocrelizumab and other anti‐CD20 therapies in the treatment of MS, as well as safety and practical considerations for prescribing are reviewed.
Journal ArticleDOI
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: An infectious diseases perspective (agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52)
Malgorzata Mikulska,Simone Lanini,Carlota Gudiol,Lubos Drgona,Giuseppe Ippolito,Mario Fernández-Ruiz,Bernd Salzberger +6 more
TL;DR: The safety profile of agents targeting CD19, CD20 and CD52 is reviewed and prevention strategies for cytomegalovirus infection, and screening for HBV, hepatitis C virus and tuberculosis are suggested.
Journal ArticleDOI
Polyphenols in the treatment of autoimmune diseases.
Haroon Khan,Antoni Sureda,Tarun Belwal,Sümeyra Çetinkaya,Ipek Süntar,Silvia Tejada,Hari Prasad Devkota,Hammad Ullah,Michael Aschner +8 more
TL;DR: Putative points of action of polyphenols in autoimmune diseases are discussed, characterizing their efficacy and safety as therapeutic agents in managing autoimmune disorders.
Journal ArticleDOI
Current perspective on rituximab in rheumatic diseases.
TL;DR: RTX, a monoclonal antibody directed to CD20 molecules expressed on the surfaces of pre-B and mature B lymphocytes, is of the most interest to rheumatologists as it represents an important additional therapeutic approach and the advent in clinical practice of approved RTX biosimilars may be of help in improving treatment access as well as in reducing costs.
References
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Journal Article
Prevention and control of influenza : recommendations of the Advisory Committee on Immunization Practices (ACIP)
TL;DR: This report updates the 2000 recommendations by the Advisory Committee on Immunization Practices on the use of influenza vaccine and antiviral agents with new or updated information regarding the cost-effectiveness of influenza vaccination and the 2001-2002 trivalent vaccine virus strains.
Journal ArticleDOI
Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
Journal ArticleDOI
2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
Jasvinder A. Singh,Kenneth G. Saag,S. Louis Bridges,Elie A. Akl,Raveendhara R. Bannuru,Matthew C. Sullivan,Elizaveta E. Vaysbrot,Christine McNaughton,Mikala C. Osani,Robert H. Shmerling,Jeffrey R. Curtis,Daniel E. Furst,Deborah Parks,Arthur Kavanaugh,James R. O'Dell,Charles H. King,Amye Leong,Eric L. Matteson,John T. Schousboe,Barbara E. Drevlow,Seth Ginsberg,James Grober,E. William St. Clair,Elizabeth A. Tindall,Amy S. Miller,Timothy E. McAlindon +25 more
TL;DR: To develop a new evidence‐based, pharmacologic treatment guideline for rheumatoid arthritis (RA), a large number of patients with RA are referred to a single clinic for treatment with these medications.
Journal ArticleDOI
Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2020-21 Influenza Season.
Lisa A. Grohskopf,Leslie Z. Sokolow,Leslie Z. Sokolow,Sonja J. Olsen,Joseph S. Bresee,Karen R. Broder,Ruth A. Karron +6 more
TL;DR: This report updates the 2017–18 recommendations of the Advisory Committee on Immunization Practices regarding the use of seasonal influenza vaccines in the United States and focuses on the recommendations for use of vaccines for the prevention and control of influenza during the 2018–19 season.
Journal ArticleDOI
The mortality of rheumatoid arthritis
Frederick Wolfe,Donald M. Mitchell,John Sibley,James F. Fries,Daniel A. Bloch,Catherine A. Williams,Patricia W. Spitz,May Haga,S M Kleinheksel,M. A. Cathey +9 more
TL;DR: Mortality rates are increased at least 2-fold in RA, and are linked to clinical severity, with a large excess of deaths attributable to cardiovascular and cerebrovascular diseases.
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