Journal ArticleDOI
X-linked thrombocytopenia caused by a novel mutation of GATA-1.
TLDR
The findings help describe a novel mutation of GATA-1 in humans as a cause of X-linked thrombocytopenia, and they confirm the vital role played by this transcription factor during in vivo megakaryocyte development.About:
This article is published in Blood.The article was published on 2001-11-01. It has received 198 citations till now. The article focuses on the topics: Zinc finger & Mutation.read more
Citations
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Journal ArticleDOI
Transcriptional Regulatory Elements in the Human Genome
TL;DR: The methods currently used to identify transcriptional regulatory elements are discussed, and the ability of these methods to be scaled up for the purpose of annotating the entire human genome is discussed.
Journal ArticleDOI
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome.
Joshua B. Wechsler,Marianne E. Greene,Michael A. McDevitt,John Anastasi,Judith E. Karp,Michelle M. Le Beau,John D. Crispino +6 more
TL;DR: It is shown that leukemic cells from every individual with DS-AMKL contain mutations in GATA1, encoding the essential hematopoietic transcription factor Gata1 (GATA binding protein 1 or globin transcription factor 1), and that loss of wildtype GATA 1 constitutes one step in the pathogenesis of AMKL in Down syndrome.
Journal ArticleDOI
The biogenesis of platelets from megakaryocyte proplatelets
TL;DR: The process of platelet assembly is described in detail and several disorders that affect platelet production are discussed, including thrombocytopenia, which can lead to inadequate clot formation and increased risk of bleeding.
Journal ArticleDOI
GATA1 function, a paradigm for transcription factors in hematopoiesis.
TL;DR: GATA1 has been in the floodlight of modern biology as a paradigm for hematopoietic transcription factors in general and GATA factors in particular since its first description in 1988.
Journal ArticleDOI
RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation
Kamaleldin E. Elagib,Frederick K. Racke,Michael Mogass,Rina Khetawat,Lorrie L. Delehanty,Adam N. Goldfarb +5 more
TL;DR: RUNX1 may participate in the programming of megakaryocytic lineage commitment through functional and physical interactions with GATA transcription factors, and RUNX1-ETO inhibition of GATA function may constitute a potential mechanism for the blockade of erythroid and megakarianocyte differentiation seen in leukemias with t(8;21).
References
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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.
D B Smith,Kevin S. Johnson +1 more
TL;DR: Plasmid expression vectors have been constructed that direct the synthesis of foreign polypeptides in Escherichia coli as fusions with the C terminus of Sj26, a 26-kDa glutathione S-transferase (GST; EC 2.5.1.18) encoded by the parasitic helminth Schistosoma japonicum.
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Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
TL;DR: A novel gene, WASP, which is expressed in lymphocytes, spleen, and thymus is isolated and is likely to be a key regulator of lymphocyte and platelet function.
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Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
TL;DR: The findings conclusively establish the essential role for GATA-1 in erythropoiesis within the context of the intact developing mouse and demonstrate that the block to cellular maturation is similar in Gata-1- embryonic and definitive erythroid precursors.
Journal ArticleDOI
FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation
Alice P. Tsang,Jane E. Visvader,C.Alexander Turner,Yuko Fujiwara,Yuko Fujiwara,Channing Yu,Mitchell J. Weiss,Merlin Crossley,Stuart H. Orkin,Stuart H. Orkin +9 more
TL;DR: Findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors.
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A lineage‐selective knockout establishes the critical role of transcription factor GATA‐1 in megakaryocyte growth and platelet development
Ramesh A. Shivdasani,Yuko Fujiwara,Yuko Fujiwara,Yuko Fujiwara,Michael A. McDevitt,Stuart H. Orkin +5 more
TL;DR: A critical role for GATA‐1 is revealed in megakaryocyte growth regulation and platelet biogenesis, and targeted mutation of cis‐elements can generate lineage‐specific knockout mice are illustrated.