Yeast Spontaneous Mutation Rate and Spectrum Vary with Environment.
Haoxuan Liu,Jianzhi Zhang +1 more
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TLDR
Observations indicate that environmental changes, which are ubiquitous in nature, influence not only natural selection, but also the amount and type of mutations available to selection, and suggest that ignoring the latter impact, as is currently practiced, may mislead evolutionary inferences.About:
This article is published in Current Biology.The article was published on 2019-05-20 and is currently open access. It has received 75 citations till now. The article focuses on the topics: Mutation rate & Mutation (genetic algorithm).read more
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Chance and necessity in the pleiotropic consequences of adaptation for budding yeast
Elizabeth R. Jerison,Elizabeth R. Jerison,Alex N. Nguyen Ba,Michael M. Desai,Sergey Kryazhimskiy +4 more
TL;DR: It is found that evolution led to diverse pleiotropic fitness gains and losses, driven by multiple types of mutations, and whether a population evolves towards a specialist or a generalist phenotype is heavily influenced by chance.
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Antagonistic pleiotropy conceals molecular adaptations in changing environments.
Piaopiao Chen,Jianzhi Zhang +1 more
TL;DR: In this article, a lower nonsynonymous to synonymous rate ratio was observed in antagonistic changing environments than in the corresponding constant environments, and the population dynamics of mutations supported the hypothesis.
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Accurate Tracking of the Mutational Landscape of Diploid Hybrid Genomes
Lorenzo Tattini,Nicolò Tellini,Simone Mozzachiodi,Melania D’Angiolo,Sophie Loeillet,Alain Nicolas,Gianni Liti +6 more
TL;DR: An integrated experimental and computational workflow to accurately track the mutational landscape of yeast diploid hybrids (MuLoYDH) in terms of single-nucleotide variants, small insertions/deletions, copy-number variants, aneuploidies, and loss-of-heterozygosity is presented.
Journal ArticleDOI
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus.
Michael Habig,Michael Habig,Cécile Lorrain,Cécile Lorrain,Alice Feurtey,Alice Feurtey,Jovan Komluski,Jovan Komluski,Eva H. Stukenbrock,Eva H. Stukenbrock +9 more
TL;DR: In this article, the direct impact of epigenetic modifications and temperature stress on mitotic mutation rates in a fungal pathogen using a mutation accumulation approach was determined, and it was shown that epigenetic modification and environmental conditions significantly increased the mutation rate.
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Thermal stress accelerates Arabidopsis thaliana mutation rate
Eric J. Belfield,Carly Brown,Zhong Jie Ding,Zhong Jie Ding,Lottie Chapman,Lottie Chapman,Mengqian Luo,Mengqian Luo,Eleanor Hinde,Sam W. van Es,Sam W. van Es,Sophie Johnson,Youzheng Ning,Youzheng Ning,Shao Jian Zheng,Aziz Mithani,Nicholas P. Harberd +16 more
TL;DR: In this article, the effects of increasing environmental temperature on plant mutation rates and relative impact on specific mutational classes (e.g., insertion/deletion [indel] vs. single nucleotide variant [SNV]) are unknown.
References
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