Adam E. Locke

TL;DR: This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI.

TL;DR: This work uses ∼36 million singleton variants from 3,560 whole-genome sequences to infer fine-scale patterns of mutation rate heterogeneity and provides the most refined portrait to date of the factors contributing to genome-wide variability of the human germline mutation rate.

TL;DR: Seven common genetic variants that modulate COVID-19 susceptibility and severity are identified, implicating IFNAR2, CCHCR1, TCF19, SLC6A20 and the hyaluronan pathway as potential therapeutic targets.

TL;DR: In this article , the authors report results from the Bipolar exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder matched with 14,422 controls, finding an excess of ultra-rare protein-truncating variants (PTVs) in patients with BD among genes under strong evolutionary constraint in both major BD subtypes.

TL;DR: Characteristics of maternal chromosomes 21 that exhibited multiple recombinant events on 21q are examined to determine whether additional risk factors or mechanisms are suggested and to better understand mechanisms that may underlie both age-related and nonage-related meiotic chromosome mal-segregation.