A
Adam E. Locke
Researcher at Washington University in St. Louis
Publications - 105
Citations - 16087
Adam E. Locke is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Exome sequencing. The author has an hindex of 35, co-authored 86 publications receiving 12473 citations. Previous affiliations of Adam E. Locke include University of Michigan & Emory University.
Papers
More filters
Journal ArticleDOI
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma
Kavita Praveen,Gaurang Patel,Lauren Gurski,Ariane Ayer,Trikaladarshi Persaud,Matthew Still,Lawrence Miloscio,Tavé van Zyl,Silvio Alessandro Di Gioia,Ben Michael Brumpton,Kristi Krebs,Bjørn Olav Åsvold,Esteban Chen,Venkata R M Chavali,Wen Fury,Harini V. Gudiseva,Sarah Hyde,Eric Jorgenson,Stephanie Lefebvre,Dadong Li,Alexander H. Li,James Mclninch,Brijeshkumar Patel,Jeremy S. Rabinowitz,Rebecca Salowe,Claudia Schurmann,Anne-Sofie Seidelin,Elisabeth Stahl,Dylan Sun,Tanya M. Teslovich,Anne Tybjærg-Hansen,Cristen J. Willer,Scott Waldron,Sabrina Walley,Hua Yang,Sarthak R Zaveri,Gonçalo R. Abecasis,Michael Cantor,Andrew Deubler,Luca A. Lotta,John D. Overton,Jeffrey G. Reid,Alan R. Shuldiner,Katherine A. Siminovitch,Christina Beechert,Caitlin Forsythe,Erin D. Fuller,Zhenhua Gu,Michael Lattari,Alexander Lopez,Thomas D. Schleicher,Maria Sotiropoulos Padilla,Louis Widom,Sarah E. Wolf,Manasi Pradhan,Kia Manoochehri,Ricardo H. Ulloa,Xiaodong Bai,Suganthi Balasubramanian,Suying Bao,Boris Boutkov,Siying Chen,Gi Seon Eom,Lukas Habegger,Alicia Hawes,Shareef Khalid,Olga A. Krasheninina,Rouel Lanche,Adam Mansfield,Evan Maxwell,Mona Nafde,Sean O’Keeffe,Max Orelus,Razvan Panea,Tommy Polanco,Ayesha Ghulam Rasool,William J Salerno,Kathie Sun,Amelia Nilanjana Sameer Deepika Jeffery C. Ashish Averitt Banerjee Malhotra Sharma Staples Yadav,Amelia J Averitt,Nilanjana Banerjee,Sameer Malhotra,Deepika Sharma,Jeff Staples,Ashish Yadav,Joshua D. Backman,Amy Damask,L. Dobbyn,Manuel A. R. Ferreira,Arkopravo Ghosh,Christopher Gillies,Hyun Min Kang,Michael Kessler,Jack A. Kosmicki,Nan Lin,Daren Liu,Adam E. Locke,Jonathan Marchini,Anthony Marcketta,Joelle Mbatchou,Arden Moscati,Charles Paulding,Carlo Sidore,Kyoko Watanabe,Bin Ye,B. Zhang,Andrey Ziyatdinov,Michelle G. Jason Lyndon J. Nirupama Nadia LeBlanc Mighty Mitnaul Nishtala Rana,Michelle G. LeBlanc,Jason Mighty,Lyndon J. Mitnaul,N. Sudhir Nishtala,N. Rana,Lance J. Adams,Jackie Blank,Dale L. Bodian,Derek Boris,Adam Lamar Buchanan,David J. Carey,Ryan Colonie,F. Daniel Davis,Dustin N. Hartzel,Melissa Kelly,H. Lester Kirchner,Joseph B. Leader,David H. Ledbetter,J. Neil Manus,Christa Lese Martin,Raghu Metpally,Michelle Meyer,Tooraj Mirshahi,Matthew T. Oetjens,Thomas N. Person,Christopher D. Still,Natasha T. Strande,Amy Buenning. Sturm,Jennie M. Wagner,Marc Joseph Williams,Andres Mari Reedik Tõnu Metspalu Nelis Mägi Esko,Andres Metspalu,Mari Nelis,Reedik Mägi,Tõnu Esko,Ying Hu,Kristian Hveem,Olle Melander,Lili Milani,Stefan Stender,Joan M. O'Brien,Marcus B. Jones,J. Weyne,Katia Karalis,Aris Bass Economides,G. Della Gatta,George D. Yancopoulos,Aris Baras,Carmelo Romano,Giovanni Coppola +157 more
TL;DR: In this article , the authors identify and functional characterization of rare coding variants (including loss-of-function variants) in ANGPTL7 associated with reduction in intraocular pressure (IOP) and glaucoma protection.
Journal ArticleDOI
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (vol 4, 170179, 2017)
Jason Flannick,Christian Fuchsberger,Anubha Mahajan,Tanya M. Teslovich,Vineeta Agarwala,Kyle J. Gaulton,Lizz Caulkins,Ryan Koesterer,Clement Ma,Loukas Moutsianas,Davis J. McCarthy,Manuel A. Rivas,John R. B. Perry,Xueling Sim,Thomas W. Blackwell,Neil R. Robertson,N. William Rayner,Pablo Cingolani,Adam E. Locke,Juan Fernandez Tajes,Heather M. Highland,Josée Dupuis,Peter S. Chines,Cecilia M. Lindgren,Christopher Hartl,Anne U. Jackson,Han Chen,Jeroen R. Huyghe,Martijn van de Bunt,Richard D. Pearson,Ashok Kumar,Martina Mueller-Nurasyid,Niels Grarup,Heather M. Stringham,Eric R. Gamazon,Jae-Hoon Lee,Yi Chen,Robert A. Scott,Jennifer E. Below,Peng Chen,Jinyan Huang,Min Jin Go,Michael L. Stitzel,Dorota Pasko,Stephen C. J. Parker,Tibor V. Varga,Todd Green,Nicola L. Beer,Aaron G. Day-Williams,Teresa Ferreira,Tasha E. Fingerlin,Momoko Horikoshi,Cheng Hu,Iksoo Huh,Mohammad Kamran Ikram,Bong-Jo Kim,Yongkang Kim,Young-Jin Kim,Min-Seok Kwon,Juyoung Lee,Selyeong Lee,Keng-Han Lin,Taylor J. Maxwell,Yoshihiko Nagai,Xu Wang,Ryan P. Welch,Joon Yoon,Weihua Zhang,Nir Barzilai,Benjamin F. Voight,Bok-Ghee Han,Christopher P. Jenkinson,Teemu Kuulasmaa,Johanna Kuusisto,Alisa K. Manning,Maggie C.Y. Ng,Nicholette D. Palmer,Beverley Balkau,Alena Stančáková,Hanna E. Abboud,Heiner Boeing,Vilmantas Giedraitis,Dorairaj Prabhakaran,Omri Gottesman,James F. Scott,Jason Carey,Phoenix Kwan,George B. Grant,Joshua D. Smith,Benjamin M. Neale,Shaun Purcell,Adam S. Butterworth,Joanna M. M. Howson,Heung Man Lee,Yingchang Lu,Soo Heon Kwak,Wei Zhao,John Danesh,Vincent K. L. Lam,Kyong Soo Park,Danish Saleheen,Wing-Yee So,Claudia H. T. Tam,Uzma Afzal,David Aguilar,Rector Arya,Tin Aung,Edmund Chan,Carmen Navarro,Ching-Yu Cheng,Domenico Palli,Adolfo Correa,Joanne E. Curran,D Rybin,Vidya S. Farook,Sharon P. Fowler,Barry I. Freedman,Michael Griswold,Daniel E. Hale,Pamela J. Hicks,Chiea Chuen Khor,Satish Kumar,Benjamin Lehne,Dorothée Thuillier,Wei-Yen Lim,Jianjun Liu,Marie Loh,Solomon K. Musani,Sobha Puppala,William R. Scott,Loic Yengo,Sian-Tsung Tan,Herman A. Taylor,Farook Thameem,Gregory P. Wilson,Tien Yin Wong,Pål R. Njølstad,Jonathan C. Levy,Massimo Mangino,Lori L. Bonnycastle,Thomas Schwarzmayr,João Fadista,Gabriela L. Surdulescu,Christian Herder,Christopher J. Groves,Thomas Wieland,Jette Bork-Jensen,Ivan Brandslund,Cramer Christensen,Heikki A. Koistinen,Alex S. F. Doney,Leena Kinnunen,Tõnu Esko,Andrew Farmer,Liisa Hakaste,Dylan Hodgkiss,Jasmina Kravic,Valeriya Lyssenko,Mette Hollensted,Marit E. Jørgensen,Torben Jørgensen,Claes Ladenvall,Johanne Marie Justesen,Annemari Käräjämäki,Jennifer Kriebel,Wolfgang Rathmann,Lars Lannfelt,Torsten Lauritzen,Narisu Narisu,Allan Linneberg,Olle Melander,Lili Milani,Matt J. Neville,Marju Orho-Melander,Lu Qi,Qibin Qi,Michael Roden,Olov Rolandsson,Amy J. Swift,Anders Rosengren,Kathleen Stirrups,Andrew R. Wood,Evelin Mihailov,Christine Blancher,Mauricio O. Carneiro,Jared Maguire,Ryan Poplin,Khalid Shakir,Timothy R. Fennell,Mark A. DePristo,Martin Hrabé de Angelis,Panos Deloukas,Anette P. Gjesing,Goo Jun,Peter M. Nilsson,Jacquelyn Murphy,Robert C. Onofrio,Barbara Thorand,Torben Hansen,Christa Meisinger,Frank B. Hu,Bo Isomaa,Fredrik Karpe,Liming Liang,Annette Peters,Cornelia Huth,Stephen O'Rahilly,Colin N. A. Palmer,Oluf Pedersen,Rainer Rauramaa,Jaakko Tuomilehto,Veikko Salomaa,Richard M. Watanabe,Ann-Christine Syvänen,Richard N. Bergman,Dwaipayan Bharadwaj,Erwin P. Bottinger,Yoon Shin Cho,Giriraj R. Chandak,Juliana C.N. Chan,Kee Seng Chia,Mark J. Daly,Shah Ebrahim,Claudia Langenberg,Paul Elliott,Kathleen A. Jablonski,Donna M. Lehman,Weiping Jia,Ronald C.W. Ma,Toni I. Pollin,Manjinder S. Sandhu,Nikhil Tandon,Philippe Froguel,Inês Barroso,Yik Ying Teo,Eleftheria Zeggini,Ruth J. F. Loos,Kerrin S. Small,Janina S. Ried,Ralph A. DeFronzo,Harald Grallert,Benjamin Glaser,Andres Metspalu,Nicholas J. Wareham,Mark Walker,Eric Banks,Christian Gieger,Erik Ingelsson,Hae Kyung Im,Thomas Illig,Paul W. Franks,Gemma Buck,Joseph Trakalo,David Buck,Inga Prokopenko,Reedik Mägi,Lars Lind,Yossi Farjoun,Katharine R. Owen,Anna L. Gloyn,Konstantin Strauch,Tiinamaija Tuomi,Jaspal S. Kooner,Jong-Young Lee,Taesung Park,Peter Donnelly,Andrew D. Morris,Andrew T. Hattersley,Donald W. Bowden,Francis S. Collins,Gil Atzmon,John C. Chambers,Tim D. Spector,Markku Laakso,Tim M. Strom,Graeme I. Bell,John Blangero,Ravindranath Duggirala,E-Shyong Tai,Gilean McVean,Craig L. Hanis,James G. Wilson,Mark Seielstad,Timothy M. Frayling,James B. Meigs,Nancy J. Cox,Robert Sladek,Eric S. Lander,Stacey Gabriel,Karen L. Mohlke,Thomas Meitinger,Leif Groop,Gonçalo R. Abecasis,Laura J. Scott,Andrew P. Morris,Hyun Min Kang,David Altshuler,Noël P. Burtt,Jose C. Florez,Michael Boehnke,Mark I. McCarthy +300 more
TL;DR: This corrects the article DOI: 10.1038/sdata.2017.179 to S Data 2017, which indicates that S Data was first published in 2017, not S Data 2016, which was originally published in 2016.
Posted ContentDOI
Across-cohort QC analyses of genome-wide association study summary statistics from complex traits
Guo-Bo Chen,Sang Hong Lee,Matthew R. Robinson,Maciej Trzaskowski,Zhi-Xiang Zhu,Thomas W. Winkler,Felix R. Day,Damien C. Croteau-Chonka,Andrew R. Wood,Adam E. Locke,Zoltán Kutalik,Loos Rjf.,Timothy M. Frayling,Joel N. Hirschhorn,Jian Yang,Naomi R. Wray,Peter M. Visscher +16 more
TL;DR: A new set of metrics and visualization tools for GWAMA, using summary statistics from cohort-level GWASs are proposed, and a new statistic that uses the reported allelic effect sizes and their standard errors to identify significant sample overlap or heterogeneity between pairs of cohorts is proposed.
Journal ArticleDOI
Whole Exome Sequencing Enhanced Imputation Identifies 85 Metabolite Associations in the Alpine CHRIS Cohort
Eva König,Johannes Rainer,Vinicius Veri Hernandes,Giuseppe Paglia,Fabiola Del Greco M,Daniele Bottigliengo,Xianyong Yin,Lap Sum Chan,Alexander Teumer,Peter P. Pramstaller,Adam E. Locke,Christian Fuchsberger +11 more
TL;DR: An exome-wide association study on absolute concentrations of 175 metabolites in 3294 individuals provides further evidence for previously described associations, and identifies three gene-trait associations, where multiple rare variants contribute to the signal.
Supplementary Material 5
Joshua C. Randall,Thomas W. Winkler,Zoltán Kutalik,Sonja I. Berndt,Anne U. Jackson,Keri L. Monda,Tuomas O. Kilpeläinen,Tõnu Esko,Reedik Mägi,Shengxu Li,Tsegaselassie Workalemahu,Mary F. Feitosa,Damien C. Croteau Chonka,Felix R. Day,Tove Fall,Teresa Ferreira,Stefan Gustafsson,Adam E. Locke,Iain Mathieson,André Scherag,Sailaja Vedantam,Andrew R. Wood,Liming Liang,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Emmanouil T. Dermitzakis,Antigone S. Dimas,Fredrik Karpe,Josine L. Min,George Nicholson,Deborah J. Clegg,Thomas N. Person,Jon P. Krohn,Sabrina Bauer,Christa Buechler,Kristina Eisinger,Amélie Bonnefond,Philippe Froguel,Jouke-Jan Hottenga,Inga Prokopenko,Lindsay L. Waite,Tamara B. Harris,Albert V. Smith,Alan R. Shuldiner,Wendy L. McArdle,Mark J. Caulfield,Patricia B. Munroe,Henrik Grönberg,Yii-Der Ida Chen,Guo Li,Jacques S. Beckmann,Toby Johnson,Unnur Thorsteinsdottir,Maris Teder-Laving,Kay-Tee Khaw,Nicholas J. Wareham,Jing Hua Zhao,Najaf Amin,Ben A. Oostra,Aldi T. Kraja,Michael A. Province,L. Adrienne Cupples,Nancy L. Heard Costa,Jaakko Kaprio,Samuli Ripatti,Ida Surakka,Francis S. Collins,Jouko Saramies,Jaakko Tuomilehto,Antti Jula,Veikko Salomaa,Jeanette Erdmann,Christian Hengstenberg,Christina Loley,Heribert Schunkert,Claudia Lamina,H.-Erich Wichmann,Eva Albrecht,Christian Gieger,Andrew A. Hicks,Åsa Johansson,Peter P. Pramstaller,Sekar Kathiresan,Elizabeth K. Speliotes,Brenda W.J.H. Penninx,Anna-Liisa Hartikainen,Marjo-Riitta Järvelin,Ulf Gyllensten,Dorret I. Boomsma,Harry Campbell,James F. Wilson,Stephen J. Chanock,Martin Farrall,Anuj Goel,Carolina Medina-Gomez,Fernando Rivadeneira,Karol Estrada,André G. Uitterlinden,Albert Hofman,M. Carola Zillikens,Martin den Heijer,Lambertus A. Kiemeney,Andrea Maschio,Per Hall,Jonathan Tyrer,Alexander Teumer,Henry Völzke,Peter Kovacs,Anke Tönjes,Massimo Mangino,Tim D. Spector,Caroline Hayward,Igor Rudan,Alistair S. Hall,Nilesh J. Samani,Antony P. Attwood,Jennifer G. Sambrook,Joseph Hung,Lyle J. Palmer,Marja-Liisa Lokki,Juha Sinisalo,Gabrielle Boucher,Heikki V. Huikuri,Mattias Lorentzon,Claes Ohlsson,Niina Eklund,Johan G. Eriksson,Cristina Barlassina,Carlo Rivolta,Ilja M. Nolte,Harold Snieder,Melanie M. van der Klauw,Jana V. Van Vliet Ostaptchouk,Pablo V. Gejman,Jianxin Shi,Kevin B. Jacobs,Zhaoming Wang,Stephan J. L. Bakker,Irene Mateo Leach,Gerjan Navis,Pim van der Harst,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Jian Yang,Daniel I. Chasman,Paul M. Ridker,Lynda M. Rose,Terho Lehtimäki,Olli T. Raitakari,Devin Absher,Carlos Iribarren,Hanneke Basart,Kees Hovingh,Elina Hyppönen,Chris Power,Denise Anderson,John Beilby,Jennie Hui,Jennifer Jolley,Hendrik B. Sager,Stefan R. Bornstein,Peter Schwarz,Kati Kristiansson,Markus Perola,Jaana Lindström,Amy J. Swift,Matti Uusitupa,Mustafa Atalay,Timo A. Lakka,Rainer Rauramaa,Jennifer L. Bolton,Gerry Fowkes,Ross M. Fraser,Jackie F. Price,Krista Fischer,Kaarel KrjutÅ¡kov,Andres Metspalu,Evelin Mihailov,Claudia Langenberg,Jian'an Luan,Ken K. Ong,Peter S. Chines,Sirkka M. Keinanen Kiukaanniemi,Timo Saaristo,Sarah Edkins,Paul W. Franks,Göran Hallmans,Dmitry Shungin,Andrew D. Morris,Colin N. A. Palmer,Raimund Erbel,Susanne Moebus,Markus M. Nöthen,Sonali Pechlivanis,Kristian Hveem,Narisu Narisu,Anders Hamsten,Steve E. Humphries,Rona J. Strawbridge,Elena Tremoli,Harald Grallert,Barbara Thorand,Thomas Illig,Wolfgang Koenig,Martina Müller-Nurasyid,Annette Peters,Bernhard O. Boehm,Marcus E. Kleber,Winfried März,Bernhard R. Winkelmann,Johanna Kuusisto,Markku Laakso,Dominique Arveiler,Giancarlo Cesana,Kari Kuulasmaa,Jarmo Virtamo,John Yarnell,Diana Kuh,Andrew Wong,Lars Lind,Ulf de Faire,Bruna Gigante,Patrik K. E. Magnusson,Nancy L. Pedersen,George Dedoussis,Maria Dimitriou,Genovefa Kolovou,Stavroula Kanoni,Kathleen Stirrups,Lori L. Bonnycastle,Inger Njølstad,Tom Wilsgaard,Andrea Ganna,Emil Rehnberg,Aroon D. Hingorani,Mika Kivimäki,Meena Kumari,Themistocles L. Assimes,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Erik Ingelsson,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,David Schlessinger,David P. Strachan,Kari Stefansson,Cornelia M. van Duijn,Gonçalo R. Abecasis,Mark I. McCarthy,Joel N. Hirschhorn,Lu Qi,Ruth J. F. Loos,Cecilia M. Lindgren,Kari E. North,Iris M. Heid +263 more