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Adam E. Locke

Researcher at Washington University in St. Louis

Publications -  105
Citations -  16087

Adam E. Locke is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Exome sequencing. The author has an hindex of 35, co-authored 86 publications receiving 12473 citations. Previous affiliations of Adam E. Locke include University of Michigan & Emory University.

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Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity

Sara Hägg, +23 more
- 16 Sep 2015 - 
TL;DR: The results indicate that gene-based meta-analysis of GWAS provides a useful strategy to find loci of interest that were not identified in standard single-marker analyses due to high allelic heterogeneity.
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Alisa K. Manning, +312 more
- 01 Jul 2017 - 
TL;DR: The allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis is extended and bidirectional effects of variants within the pleckstrin homology domain ofAKT2 are demonstrated.
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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

James P. Davis, +19 more
- 30 Oct 2017 - 
TL;DR: Gene-based associations (P<10−10) support a role for coding variants in LIPC and LIPG with lipoprotein subclass traits and novel association signals provide further insight into the molecular basis of dyslipidemia and the etiology of metabolic disorders.
Posted ContentDOI

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan, +105 more
- 09 Jan 2018 - 
TL;DR: Increase in sample size and variant diversity deliver enhanced discovery and single-variant resolution of causal T2D-risk alleles, and the consequent impact on mechanistic insights and clinical translation is highlighted.
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Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: A report from the National Down Syndrome Project

Lora J. H. Bean, +13 more
- 01 Oct 2011 - 
TL;DR: The results suggest that lack of maternal folic acid supplementation is associated with septal defects in infants with Down syndrome.