A
Adam E. Locke
Researcher at Washington University in St. Louis
Publications - 105
Citations - 16087
Adam E. Locke is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Exome sequencing. The author has an hindex of 35, co-authored 86 publications receiving 12473 citations. Previous affiliations of Adam E. Locke include University of Michigan & Emory University.
Papers
More filters
Journal ArticleDOI
Quality control and conduct of genome-wide association meta-analyses
Thomas W. Winkler,Felix R. Day,Damien C. Croteau-Chonka,Andrew R. Wood,Adam E. Locke,Reedik Mägi,Teresa Ferreira,Tove Fall,Mariaelisa Graff,Anne E. Justice,Jian'an Luan,Stefan Gustafsson,Joshua C. Randall,Sailaja Vedantam,Tsegaselassie Workalemahu,Tuomas O. Kilpeläinen,André Scherag,Tõnu Esko,Zoltán Kutalik,Iris M. Heid,Ruth J. F. Loos +20 more
TL;DR: In this article, a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data is presented. But this protocol is not suitable for large consortia such as the GIANT Consortium.
Journal ArticleDOI
Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project.
Sallie B. Freeman,Lora J. H. Bean,Emily G. Allen,Stuart W. Tinker,Adam E. Locke,Charlotte M. Druschel,Charlotte A. Hobbs,Paul A. Romitti,Marjorie H. Royle,Claudine P. Torfs,Kenneth J. Dooley,Stephanie L. Sherman +11 more
TL;DR: Sex and ethnic differences exist for atrioventricular septal defects in Down syndrome and identification of genetic and environmental risk factors associated with these differences is essential to the authors' understanding of the etiology of congenital heart defects.
Journal ArticleDOI
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Valérie Turcot,Yingchang Lu,Yingchang Lu,Heather M. Highland,Heather M. Highland,Claudia Schurmann,Anne E. Justice,Rebecca S. Fine,Rebecca S. Fine,Jonathan P. Bradfield,Tõnu Esko,Tõnu Esko,Tõnu Esko,Ayush Giri,Mariaelisa Graff,Xiuqing Guo,Audrey E. Hendricks,Audrey E. Hendricks,Tugce Karaderi,Tugce Karaderi,Adelheid Lempradl,Adam E. Locke,Adam E. Locke,Anubha Mahajan,Eirini Marouli,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kristin L. Young,Tamuno Alfred,Mary F. Feitosa,Nicholas G. D. Masca,Nicholas G. D. Masca,Alisa K. Manning,Alisa K. Manning,Carolina Medina-Gomez,Poorva Mudgal,Maggie C.Y. Ng,Alexander P. Reiner,Alexander P. Reiner,Sailaja Vedantam,Sailaja Vedantam,Sara M. Willems,Thomas W. Winkler,Gonçalo R. Abecasis,Katja K.H. Aben,Dewan S. Alam,Sameer E. Al-Harthi,Sameer E. Al-Harthi,Matthew A. Allison,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Folkert W. Asselbergs,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Lia E. Bang,Inês Barroso,Inês Barroso,Lisa Bastarache,Marianne Benn,Sven Bergmann,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Gerome Breen,Murray H. Brilliant,Linda Broer,Marco Brumat,Amber A. Burt,Adam S. Butterworth,Peter T. Campbell,Stefania Cappellani,David J. Carey,Eulalia Catamo,Mark J. Caulfield,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Amanda J. Cox,David S. Crosslin,Gabriel Cuellar-Partida,Gabriel Cuellar-Partida,Angela D'Eustacchio,John Danesh,John Danesh,Gail Davies,Gail Davies,Paul I.W. de Bakker,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Martin den Heijer,Anneke I. den Hollander,Hester M. den Ruijter,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Fotios Drenos,Fotios Drenos,Mengmeng Du,Mengmeng Du,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Todd L. Edwards,David Ellinghaus,Patrick T. Ellinor,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Aliki-Eleni Farmaki,Aliki-Eleni Farmaki,I. Sadaf Farooqi,Jessica D. Faul,Sascha Fauser,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Jose C. Florez,Ian Ford,Myriam Fornage,Oscar H. Franco,Andre Franke,Paul W. Franks,Paul W. Franks,Paul W. Franks,Nele Friedrich,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Jane Gibson,Vilmantas Giedraitis,Anette P. Gjesing,Penny Gordon-Larsen,Mathias Gorski,Hans-Jörgen Grabe,Hans-Jörgen Grabe,Struan F.A. Grant,Niels Grarup,Helen Griffiths,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Hakon Hakonarson,Anke R. Hammerschlag,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Christian Theil Have,Caroline Hayward,Liang He,Liang He,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Andrew C. Heath,Iris M. Heid,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Paul L. Huang,Jennifer E. Huffman,M. Arfan Ikram,Erik Ingelsson,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Yucheng Jia,Stefan Johansson,Marit E. Jørgensen,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,J. Wouter Jukema,Bratati Kahali,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Sekar Kathiresan,Sekar Kathiresan,Frank Kee,Lambertus A. Kiemeney,Eric Kim,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Jaspal S. Kooner,Charles Kooperberg,Tellervo Korhonen,Tellervo Korhonen,Tellervo Korhonen,Peter Kovacs,Helena Kuivaniemi,Helena Kuivaniemi,Zoltán Kutalik,Zoltán Kutalik,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,David Lamparter,Ethan M. Lange,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Eric B. Larson,Nanette R. Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Keng-Hung Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Yongmei Liu,Ken Sin Lo,Artitaya Lophatananon,Andrew J. Lotery,Anu Loukola,Jian'an Luan,Steven A. Lubitz,Steven A. Lubitz,Leo-Pekka Lyytikäinen,Satu Männistö,Gaëlle Marenne,Angela L. Mazul,Mark I. McCarthy,Roberta McKean-Cowdin,Sarah E. Medland,Karina Meidtner,Lili Milani,Vanisha Mistry,Paul Mitchell,Karen L. Mohlke,Leena Moilanen,Marie Moitry,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Carmel Moore,Trevor A. Mori,Andrew D. Morris,Andrew P. Morris,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Narisu Narisu,Christopher P. Nelson,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Dale R. Nyholt,Dale R. Nyholt,Jeffrey R. O'Connel,Michelle L. O'Donoghue,Loes M. Olde Loohuis,Roel A. Ophoff,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Nicholette D. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,Markus Perola,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Tune H. Pers,Thomas N. Person,Annette Peters,Eva Rb Petersen,Patricia A. Peyser,Ailith Pirie,Ozren Polasek,Ozren Polasek,Tinca J. C. Polderman,Hannu Puolijoki,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Frida Renström,Frida Renström,Myriam Rheinberger,Paul M. Ridker,John D. Rioux,Manuel A. Rivas,Manuel A. Rivas,David J. Roberts,David J. Roberts,David J. Roberts,Neil R. Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Yadav Sapkota,Naveed Sattar,Robert E. Schoen,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Wayne H-H Sheu,Wayne H-H Sheu,Xueling Sim,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Albert V. Smith,Lorraine Southam,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kari Stefansson,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Liang Sun,Praveen Surendran,Amy J. Swift,Hayato Tada,Hayato Tada,Katherine E. Tansey,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Gerard Tromp,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Matti Uusitupa,Sander W. van der Laan,Cornelia M. van Duijn,Nienke van Leeuwen,Nienke van Leeuwen,Jessica van Setten,Mauno Vanhala,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Giovanni Veronesi,Henrik Vestergaard,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Uwe Völker,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Erin B. Ware,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Daniel R. Witte,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Laura M. Yerges-Armstrong,Robin Young,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhao,Wei Zhou,Krina T. Zondervan,Jerome I. Rotter,John Andrew Pospisilik,Fernando Rivadeneira,Ingrid B. Borecki,Panos Deloukas,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Kari E. North,Cecilia M. Lindgren,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos +489 more
TL;DR: Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Journal ArticleDOI
Population genetic differentiation of height and body mass index across Europe
Matthew R. Robinson,Gibran Hemani,Carolina Medina-Gomez,Massimo Mezzavilla,Tõnu Esko,Tõnu Esko,Tõnu Esko,Konstantin Shakhbazov,Joseph E. Powell,Anna A. E. Vinkhuyzen,Sonja I. Berndt,Stefan Gustafsson,Anne E. Justice,Bratati Kahali,Adam E. Locke,Tune H. Pers,Tune H. Pers,Tune H. Pers,Sailaja Vedantam,Sailaja Vedantam,Andrew R. Wood,Wouter van Rheenen,Ole A. Andreassen,Paolo Gasparini,Andres Metspalu,Leonard H. van den Berg,Jan H. Veldink,Fernando Rivadeneira,Thomas Werge,Thomas Werge,Gonçalo R. Abecasis,Dorret I. Boomsma,Dorret I. Boomsma,Daniel I. Chasman,Eco J. C. de Geus,Eco J. C. de Geus,Timothy M. Frayling,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Erik Ingelsson,Erik Ingelsson,Ruth J. F. Loos,Ruth J. F. Loos,Patrik K. E. Magnusson,Nicholas G. Martin,Grant W. Montgomery,Kari E. North,Kari E. North,Nancy L. Pedersen,Tim D. Spector,Elizabeth K. Speliotes,Michael E. Goddard,Michael E. Goddard,Jian Yang,Peter M. Visscher +57 more
TL;DR: It is found that many independent loci contribute to population genetic differences in height and body mass index in 9,416 individuals across 14 European countries.
Journal ArticleDOI
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Yingchang Lu,Felix R. Day,Stefan Gustafsson,Stefan Gustafsson,Martin L. Buchkovich,Jianbo Na,Veronique Bataille,Veronique Bataille,Diana L. Cousminer,Zari Dastani,Alexander W. Drong,Tõnu Esko,David M. Evans,Mario Falchi,Mario Falchi,Mary F. Feitosa,Teresa Ferreira,Åsa K. Hedman,Robin Haring,Robin Haring,Pirro G. Hysi,Mark M. Iles,Anne E. Justice,Stavroula Kanoni,Stavroula Kanoni,Vasiliki Lagou,Rui Li,Xin Li,Adam E. Locke,Chen Lu,Reedik Mägi,John R. B. Perry,Tune H. Pers,Qibin Qi,Marianna Sanna,Marianna Sanna,Ellen M. Schmidt,William R. Scott,William R. Scott,Dmitry Shungin,Dmitry Shungin,Alexander Teumer,Anna A. E. Vinkhuyzen,Ryan W. Walker,Harm-Jan Westra,Mingfeng Zhang,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Zhihong Zhu,Uzma Afzal,Uzma Afzal,Tarunveer S. Ahluwalia,Stephan J. L. Bakker,Claire Bellis,Amélie Bonnefond,Amélie Bonnefond,Katja Borodulin,Aron S. Buchman,Tommy Cederholm,Audrey C. Choh,Hyung Jin Choi,Joanne E. Curran,Lisette C. P. G. M. de Groot,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Rosalie A. M. Dhonukshe-Rutten,Anke W. Enneman,Elodie Eury,Elodie Eury,Daniel S. Evans,Tom Forsén,Nele Friedrich,Frédéric Fumeron,Melissa E. Garcia,Simone Gärtner,Bok-Ghee Han,Aki S. Havulinna,Caroline Hayward,Dena G. Hernandez,Hans L. Hillege,Till Ittermann,Jack W. Kent,Ivana Kolcic,Tiina Laatikainen,Tiina Laatikainen,Jari Lahti,Irene Mateo Leach,Christine G. Lee,Christine G. Lee,Jong-Young Lee,Tian Liu,Youfang Liu,Stéphane Lobbens,Stéphane Lobbens,Marie Loh,Marie Loh,Leo-Pekka Lyytikäinen,Carolina Medina-Gomez,Karl Michaëlsson,Mike A. Nalls,Carrie M. Nielson,Laticia Oozageer,Laura Pascoe,Lavinia Paternoster,Ozren Polasek,Ozren Polasek,Samuli Ripatti,Samuli Ripatti,Mark A. Sarzynski,Chan Soo Shin,Nina Smolej Narančić,Dominik Spira,Priya Srikanth,Elisabeth Steinhagen-Thiessen,Yun Ju Sung,Karin M. A. Swart,Karin M. A. Swart,Leena Taittonen,Toshiko Tanaka,Emmi Tikkanen,Nathalie van der Velde,Natasja M. van Schoor,Natasja M. van Schoor,Niek Verweij,Alan F. Wright,Lei Yu,Joseph M. Zmuda,Niina Eklund,Terrence Forrester,Niels Grarup,Anne U. Jackson,Kati Kristiansson,Kati Kristiansson,Teemu Kuulasmaa,Johanna Kuusisto,Peter Lichtner,Jian'an Luan,Anubha Mahajan,Satu Männistö,Cameron D. Palmer,Cameron D. Palmer,Janina S. Ried,Robert A. Scott,Alena Stančáková,Peter Wagner,Peter Wagner,Ayse Demirkan,Angela Döring,Vilmundur Gudnason,Douglas P. Kiel,Brigitte Kühnel,Massimo Mangino,Barbara McKnight,Barbara McKnight,Cristina Menni,Jeffrey R. O'Connell,Ben A. Oostra,Alan R. Shuldiner,Alan R. Shuldiner,Kijoung Song,Liesbeth Vandenput,Cornelia M. van Duijn,Peter Vollenweider,Charles C. White,Michael Boehnke,Yvonne Boettcher,Richard S. Cooper,Nita G. Forouhi,Christian Gieger,Harald Grallert,Aroon D. Hingorani,Torben Jørgensen,Torben Jørgensen,Pekka Jousilahti,Mika Kivimäki,Meena Kumari,Markku Laakso,Claudia Langenberg,Allan Linneberg,Amy Luke,Colin A. McKenzie,Aarno Palotie,Aarno Palotie,Aarno Palotie,Oluf Pedersen,Annette Peters,Konstantin Strauch,Bamidele O. Tayo,Nicholas J. Wareham,David A. Bennett,Lars Bertram,Lars Bertram,John Blangero,Matthias Blüher,Claude Bouchard,Harry Campbell,Nam H. Cho,Steven R. Cummings,Stefan A. Czerwinski,Ilja Demuth,Rahel Eckardt,Johan G. Eriksson,Johan G. Eriksson,Luigi Ferrucci,Oscar H. Franco,Philippe Froguel,Philippe Froguel,Ron T. Gansevoort,Torben Hansen,Torben Hansen,Tamara B. Harris,Nicholas D. Hastie,Markku Heliövaara,Albert Hofman,Joanne M. Jordan,Antti Jula,Mika Kähönen,Eero Kajantie,Eero Kajantie,Eero Kajantie,Paul Knekt,Seppo Koskinen,Peter Kovacs,Terho Lehtimäki,Lars Lind,Yongmei Liu,Eric S. Orwoll,Clive Osmond,Markus Perola,Markus Perola,Louis Pérusse,Olli T. Raitakari,Olli T. Raitakari,Tuomo Rankinen,Dabeeru C. Rao,Treva Rice,Fernando Rivadeneira,Igor Rudan,Veikko Salomaa,Thorkild I. A. Sørensen,Michael Stumvoll,Anke Tönjes,Bradford Towne,Gregory J. Tranah,Angelo Tremblay,André G. Uitterlinden,Pim van der Harst,Erkki Vartiainen,Jorma S. A. Viikari,Veronique Vitart,Marie-Claude Vohl,Henry Völzke,Mark Walker,Mark Walker,Henri Wallaschofski,Sarah H Wild,James F. Wilson,Loic Yengo,Loic Yengo,D. Timothy Bishop,Ingrid B. Borecki,Ingrid B. Borecki,John C. Chambers,John C. Chambers,John C. Chambers,L. Adrienne Cupples,Abbas Dehghan,Panos Deloukas,Panos Deloukas,Panos Deloukas,Ghazaleh Fatemifar,Caroline S. Fox,Terrence S. Furey,Lude Franke,Jiali Han,David J. Hunter,Juha Karjalainen,Fredrik Karpe,Robert C. Kaplan,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Mark I. McCarthy,Joanne M. Murabito,Andrew P. Morris,Andrew P. Morris,Julia A. Newton Bishop,Kari E. North,Claes Ohlsson,Ken K. Ong,Inga Prokopenko,J. Brent Richards,Eric E. Schadt,Tim D. Spector,Elisabeth Widen,Cristen J. Willer,Jian Yang,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Karen L. Mohlke,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,John Andrew Pospisilik,M. Carola Zillikens,Cecilia M. Lindgren,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Ruth J. F. Loos +311 more
TL;DR: The loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.