Weiqing Wang

TL;DR: Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

TL;DR: For the first time, specific loci that distinguish between BD and SCZ are discovered and polygenic components underlying multiple symptom dimensions are identified that point to the utility of genetics to inform symptomology and potential treatment.

TL;DR: This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

TL;DR: In this article , the authors report results from the Bipolar exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder matched with 14,422 controls, finding an excess of ultra-rare protein-truncating variants (PTVs) in patients with BD among genes under strong evolutionary constraint in both major BD subtypes.

TL;DR: Trans-ancestral meta-analysis using data from European and East Asian populations to identify ten new loci for serum urate levels and identifies candidate causal genes at 24 loci and a network of previously unidentified genes likely involved in control of serum Urate levels, further illuminating the molecular mechanisms of urate control.