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Anders Laustsen
Researcher at Aarhus University
Publications - 21
Citations - 1461
Anders Laustsen is an academic researcher from Aarhus University. The author has contributed to research in topics: Cas9 & Sting. The author has an hindex of 11, co-authored 20 publications receiving 985 citations.
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Journal ArticleDOI
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
Martin R. Jakobsen,Rasmus O. Bak,Annika Andersen,Randi K. Berg,Randi K. Berg,Søren B. Jensen,Tengchuan Jin,Anders Laustsen,Kathrine Hansen,Lars Østergaard,Katherine A. Fitzgerald,T. Sam Xiao,Jacob Giehm Mikkelsen,Trine H. Mogensen,Søren R. Paludan +14 more
TL;DR: IFI16 is a sensor for DNA forms produced during the lentiviral replication cycle and regulates HIV-1 replication in macrophages, which contribute to early control of the virus.
Journal ArticleDOI
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway
Kathrine Hansen,Thaneas Prabakaran,Anders Laustsen,Sofie E. Jørgensen,Stine H Rahbæk,Søren B. Jensen,Rikke Nielsen,Jess H. Leber,Thomas Decker,Kristy A. Horan,Martin R. Jakobsen,Søren R. Paludan +11 more
TL;DR: In human macrophages, Listeria DNA rather than cyclic‐di‐AMP is stimulating the IFN response via a pathway dependent on the DNA sensors IFI16 and cGAS as well as the signalling adaptor molecule STING.
Journal ArticleDOI
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
Kasper L Jønsson,Anders Laustsen,Christian Krapp,Christian Krapp,Kristian Alsbjerg Skipper,Karthiga Thavachelvam,Dominik Hotter,Johanne H Egedal,Mads Kjolby,Mads Kjolby,Pejman Mohammadi,Thaneas Prabakaran,Lambert K. Sørensen,Chenglong Sun,Søren B. Jensen,Christian K. Holm,Robert Jan Lebbink,Mogens Johannsen,Mette Nyegaard,Jacob Giehm Mikkelsen,Frank Kirchhoff,Søren R. Paludan,Martin R. Jakobsen +22 more
TL;DR: The results suggest that IFI16 is essential for efficient sensing and signalling upon DNA challenge in macrophages to promote interferons and antiviral responses.
Journal ArticleDOI
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
Christian K. Holm,Stine H. Rahbek,Hans Henrik Gad,Rasmus O. Bak,Martin R. Jakobsen,Zhaozaho Jiang,Anne Louise Hansen,Simon K. Jensen,Chenglong Sun,Martin K. Thomsen,Anders Laustsen,Camilla G. Nielsen,Kasper Severinsen,Yingluo Xiong,Yingluo Xiong,Dara Burdette,Veit Hornung,Robert Jan Lebbink,Mogens Duch,Katherine A. Fitzgerald,Shervin Bahrami,Jakob Giehm Mikkelsen,Rune Hartmann,Søren R. Paludan +23 more
TL;DR: A STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV), which is targeted by IAV is identified.
Journal ArticleDOI
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
David Olagnier,Aske M Brandtoft,Camilla Gunderstofte,Nikolaj L. Villadsen,Christian Krapp,Anne L. Thielke,Anders Laustsen,Suraj Peri,Anne Louise Hansen,Lene Bonefeld,Jacob Thyrsted,Victor Bruun,Marie B. Iversen,Lin Lin,Virginia M. Artegoitia,Chenhe Su,Long Yang,Rongtuan Lin,Siddharth Balachandran,Yonglun Luo,Mette Nyegaard,Bernadette Marrero,Raphaela Goldbach-Mansky,Mona Motwani,Dylan G. Ryan,Katherine A. Fitzgerald,Luke A. J. O'Neill,Anne Kruse Hollensen,Christian Kroun Damgaard,Frank Vincenzo de Paoli,Hanne Christine Bertram,Martin R. Jakobsen,Thomas B. Poulsen,Christian K. Holm +33 more
TL;DR: Nrf2 activation decreases STING expression and responsiveness to STING agonists while increasing susceptibility to infection with DNA viruses, and a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells is suggested.