Auda A. Eltahla

TL;DR: This study introduces a new paradigm whereby CD8+ T cells confer unprecedented cross-reactivity across all influenza viruses, a key finding for the design of universal vaccines.

TL;DR: It is proposed that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrated that the actions of the IF ITM proteins are indeed virus and cell-type specific.

TL;DR: It is demonstrated that single‐cell transcriptome analysis can successfully distinguish Ag‐specific T cell populations sorted directly from resting memory cells in peripheral blood and sorted after ex vivo stimulation.

TL;DR: In this paper, the diversity of circulating human B cells is examined using single-cell RNA sequencing (RNA-seq) to examine diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals.

TL;DR: Molecular and phenotypic analysis is used to establish persistence of clonally diverse CD8+ T cell populations during fatal infection and proposes that effective expansion of cross-reactive influenza-specific TCRαβ clonotypes with appropriate transcriptome signatures is needed for early protection against severe influenza disease.