Bryan Joseph San Luis

TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.

TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.

TL;DR: This work has applied the SGA score to examine the relationship between physical and genetic interaction networks, and found that positive genetic interactions connect across functionally distinct protein complexes revealing a network of genetic suppression among loss-of-function alleles.

TL;DR: The extensive network of trigenic interactions and their ability to generate functionally diverse phenotypes suggest that higher-order genetic interactions may play a key role in the genotype-to-phenotype relationship, genome size, and speciation.

TL;DR: Using computational predictions combined with traditional quantitative experiments, 100 proteins whose deficiency alters mitochondrial biogenesis and inheritance in Saccharomyces cerevisiae are identified and characterized mutants with subtle mitochondrial defects whose phenotypes were undetected by high-throughput methods.