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Carla J. Gallagher
Researcher at Pennsylvania State University
Publications - 25
Citations - 1381
Carla J. Gallagher is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 17, co-authored 25 publications receiving 1300 citations. Previous affiliations of Carla J. Gallagher include University of Cologne & Penn State Cancer Institute.
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A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
James McKay,Thérèse Truong,Valerie Gaborieau,Amelie Chabrier,Shu Chun Chuang,Graham Byrnes,David Zaridze,Oxana Shangina,Neonila Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Alexandru Bucur,Vladimir Bencko,Ivana Holcatova,Vladimir Janout,Lenka Foretova,Pagona Lagiou,Dimitrios Trichopoulos,Simone Benhamou,Christine Bouchardy,Wolfgang Ahrens,Franco Merletti,Lorenzo Richiardi,Renato Talamini,Luigi Barzan,Kristina Kjærheim,Gary J. Macfarlane,Tatiana V. Macfarlane,Lorenzo Simonato,Cristina Canova,Cristina Canova,Antonio Agudo,Xavier Castellsagué,Ray Lowry,David I. Conway,Patricia A. McKinney,Claire M. Healy,Mary Toner,Ariana Znaor,Maria Paula Curado,Sergio Koifman,Ana M. B. Menezes,Victor Wünsch-Filho,José Eluf Neto,Leticia Fernández Garrote,Stefania Boccia,Gabriella Cadoni,Dario Arzani,Andrew F. Olshan,Mark C. Weissler,William K. Funkhouser,Jingchun Luo,Jan Lubinski,Joanna Trubicka,Marcin Lener,Dorota Oszutowska,Stephen M. Schwartz,Chu Chen,Sherianne Fish,David R. Doody,Joshua E. Muscat,Philip Lazarus,Carla J. Gallagher,Shen Chih Chang,Zuo-Feng Zhang,Qingyi Wei,Erich M. Sturgis,Li E. Wang,Silvia Franceschi,Rolando Herrero,Karl T. Kelsey,Michael D. McClean,Carmen J. Marsit,Heather H. Nelson,Marjorie Romkes,Shama Buch,Tomoko Nukui,Shilong Zhong,Martin Lacko,Johannes J. Manni,Wilbert H.M. Peters,Rayjean J. Hung,John R. McLaughlin,Lars J. Vatten,Inger Njølstad,Gary E. Goodman,John K. Field,Triantafillos Liloglou,Paolo Vineis,Paolo Vineis,Françoise Clavel-Chapelon,Domenico Palli,Rosario Tumino,Vittorio Krogh,Salvatore Panico,Carlos A. González,J. Ramón Quirós,Carmen Enid Martínez,Carmen Navarro,Eva Ardanaz,Nerea Larrañaga,Kay-Tee Khaw,Timothy J. Key,H. Bas Bueno-de-Mesquita,Petra H.M. Peeters,Antonia Trichopoulou,Jakob Linseisen,Heiner Boeing,Göran Hallmans,Kim Overvad,Anne Tjønneland,Merethe Kumle,Elio Riboli,Kristjan Välk,Tõnu Voodern,Andres Metspalu,Diana Zelenika,Anne Boland,Marc Delepine,Mario Foglio,Doris Lechner,Hélène Blanché,Ivo Gut,Pilar Galan,Simon Heath,Mia Hashibe,Richard B. Hayes,Paolo Boffetta,Mark Lathrop,Paul Brennan +130 more
TL;DR: A genome-wide association study to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Journal ArticleDOI
Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium
Thérèse Truong,Rayjean J. Hung,Christopher I. Amos,Xifeng Wu,Heike Bickeböller,Albert Rosenberger,Wiebke Sauter,Thomas Illig,H.-Erich Wichmann,Angela Risch,Hendrik Dienemann,Rudolph Kaaks,Ping Yang,Ruoxiang Jiang,John K. Wiencke,Margaret Wrensch,Helen M. Hansen,Karl T. Kelsey,Keitaro Matsuo,Kazuo Tajima,Ann G. Schwartz,Angie S. Wenzlaff,Adeline Seow,Chen Ying,Andrea Staratschek-Jox,Peter Nürnberg,Erich Stoelben,Jürgen Wolf,Philip Lazarus,Joshua E. Muscat,Carla J. Gallagher,Shanbeh Zienolddiny,Aage Haugen,Henricus F. M. van der Heijden,Lambertus A. Kiemeney,Dolores Isla,Jose I. Mayordomo,Thorunn Rafnar,Kari Stefansson,Kari Stefansson,Zuo-Feng Zhang,Shen Chih Chang,Jin Hee Kim,Jin Hee Kim,Yun Chul Hong,Yun Chul Hong,Yun Chul Hong,Eric J. Duell,Angeline S. Andrew,Flavio Lejbkowicz,Gad Rennert,Heiko Müller,Hermann Brenner,Loic Le Marchand,Simone Benhamou,C. Bouchardy,M. Dawn Teare,Xiaoyan Xue,John McLaughlin,John McLaughlin,Geoffrey Liu,James McKay,Paul Brennan,Margaret R. Spitz +63 more
TL;DR: Previous associations found in white populations were replicated and new associations were identified in Asian populations, and the associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest for squamous cell carcinomas.
Journal ArticleDOI
The UDP-Glucuronosyltransferase 2B17 Gene Deletion Polymorphism: Sex-Specific Association with Urinary 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol Glucuronidation Phenotype and Risk for Lung Cancer
Carla J. Gallagher,Joshua E. Muscat,Amy N. Hicks,Yan Zheng,Anne Marie Dyer,Gary A. Chase,John P. Richie,Philip Lazarus +7 more
TL;DR: The association of the UGT2B17 deletion with increased lung adenocarcinoma in women is consistent with its association with decreased NNAL glucuronidation rates in women and with studies showing that NNal is a selective inducer of lung adanoma in experimental animals.
Journal ArticleDOI
Functional Significance of UDP-Glucuronosyltransferase Variants in the Metabolism of Active Tamoxifen Metabolites
Andrea S. Blevins-Primeau,Dongxiao Sun,Gang Chen,Arun Sharma,Carla J. Gallagher,Shantu Amin,Philip Lazarus +6 more
TL;DR: Functional polymorphisms in TAM-metabolizing UGTs, including UGT2B7 and potentially UGT1A8, may be important in interindividual variability in TAM metabolism and response to TAM therapy.
Journal ArticleDOI
Glucuronidation Genotypes and Nicotine Metabolic Phenotypes: Importance of Functional UGT2B10 and UGT2B17 Polymorphisms
Gang Chen,Nino E. Giambrone,Douglas F. Dluzen,Joshua E. Muscat,Arthur Berg,Carla J. Gallagher,Philip Lazarus +6 more
TL;DR: The data suggest that UGTs 2B10 and 2B17 play important roles in the glucuronidation of nicotine, cotinine, and 3HC and suggest that the UGT2B10 codon 67 SNP and the U GT2B17 gene deletion significantly reduce overall glucuronidated rates of nicotine and its major metabolites in smokers.