C
Changlian Zhu
Researcher at University of Gothenburg
Publications - 208
Citations - 16429
Changlian Zhu is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Neuroprotection & Apoptosis. The author has an hindex of 50, co-authored 183 publications receiving 13346 citations. Previous affiliations of Changlian Zhu include Boston Children's Hospital & Karolinska Institutet.
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Journal ArticleDOI
Association of NOS1 gene polymorphisms with cerebral palsy in a Han Chinese population: a case-control study.
Ting Yu,Lei Xia,Dan Bi,Yangong Wang,Qing Shang,Dengna Zhu,Juan Song,Yong Wang,Xiaoyang Wang,Xiaoyang Wang,Changlian Zhu,Changlian Zhu,Qinghe Xing +12 more
TL;DR: NOS1 is associated with CP’s+ NE and spastic quadriplegia, suggesting that NOS 1 is likely involved in the pathogenesis of CP and that it is a potential therapeutic target for treatment of cerebral injury.
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Cranial irradiation alters neuroinflammation and neural proliferation in the pituitary gland and induces late-onset hormone deficiency.
Yiran Xu,Yiran Xu,Yanyan Sun,Kai Zhou,Kai Zhou,Kai Zhou,Cuicui Xie,Cuicui Xie,Tao Li,Tao Li,Tao Li,Yafeng Wang,Yafeng Wang,Yafeng Wang,Yaodong Zhang,Yaodong Zhang,Juan Lantero Rodriguez,Xiaoan Zhang,Ruijin Shao,Xiaoyang Wang,Xiaoyang Wang,Changlian Zhu,Changlian Zhu,Changlian Zhu +23 more
TL;DR: It is found that brain irradiation reduced cell proliferation and induced persistent inflammation in the pituitary gland and the whole transcriptome analysis of the pituitsary gland revealed that apoptosis and inflammation‐related pathways were up‐regulated after irradiation.
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An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion
Kai Zhou,Jinming Han,Harald Lund,Nageswara Rao Boggavarapu,Volker M. Lauschke,Shinobu Goto,Huaitao Cheng,Yuyu Wang,Asuka Tachi,Cuicui Xie,Keying Zhu,Ying Sun,Ahmed M. Osman,Dong Liang,Wei Han,Kristina Gemzell-Danielsson,Christer Betsholtz,Xing-Mei Zhang,Changlian Zhu,Martin Enge,Bertrand Joseph,Robert A. Harris,Klas Blomgren +22 more
TL;DR: In this article , a subpopulation of microglia devoid of genetic modification was identified in Cx3cr1CreER-Eyfp/wt mouse brains, which constituted less than 1% of all microglias under homeostatic conditions.
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Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia
Manuela Wiessner,Reza Maroofian,Meng-Yuan Ni,Andrea Pedroni,Juliane S Müller,Rolf Stucka,Christian Beetz,Stephanie Efthymiou,Filippo M. Santorelli,Ahmed Alfares,Changlian Zhu,Changlian Zhu,Changlian Zhu,Anna Uhrova Meszarosova,Elham Alehabib,Somayeh Bakhtiari,Andreas R. Janecke,Maria Gabriela Otero,Jin Yun Helen Chen,James T Peterson,Tim M. Strom,Peter De Jonghe,Tine Deconinck,Willem De Ridder,Jonathan De Winter,Rossella Pasquariello,Ivana Ricca,Majid Alfadhel,Bart P.C. van de Warrenburg,Ruben Portier,Carsten Bergmann,Saghar Ghasemi Firouzabadi,Sheng Chih Jin,Kaya Bilguvar,Sherifa A. Hamed,Mohammed Anter Abdelhameed,Nourelhoda A Haridy,Nourelhoda A Haridy,Shazia Maqbool,Fatima Rahman,Najwa Anwar,Jenny Carmichael,Alistair T. Pagnamenta,Nicholas W. Wood,Nicholas W. Wood,Frederic Tran Mau-Them,Tobias B. Haack,Maja Di Rocco,Isabella Ceccherini,Michele Iacomino,Federico Zara,Federico Zara,Vincenzo Salpietro,Vincenzo Salpietro,Marcello Scala,Marcello Scala,Marta Rusmini,Yiran Xu,Yinghong Wang,Yasuhiro Suzuki,Kishin Koh,Haitian Nan,Hiroyuki Ishiura,Shoji Tsuji,Laetitia Lambert,Emmanuelle Schmitt,Elodie Lacaze,Hanna Küpper,David Dredge,Cara M. Skraban,Cara M. Skraban,Amy Goldstein,Amy Goldstein,Mary J H Willis,Katheryn Grand,John M. Graham,Richard A. Lewis,Francisca Millan,Özgür Duman,Nihal Olgaç Dündar,Gökhan Uyanik,Ludger Schöls,Ludger Schöls,Peter Nürnberg,Gudrun Nürnberg,Andrea Catala Bordes,Pavel Seeman,Martin Kuchar,Hossein Darvish,Adriana P. Rebelo,Filipa Bouçanova,Jean-Jacques Médard,Roman Chrast,Michaela Auer-Grumbach,Fowzan S. Alkuraya,Hanan E. Shamseldin,Saeed Al Tala,Jamileh Rezazadeh Varaghchi,Maryam Najafi,Maryam Najafi,Selina Deschner,Dieter Gläser,Wolfgang Hüttel,Michael C. Kruer,Erik-Jan Kamsteeg,Yoshihisa Takiyama,Stephan Züchner,Jonathan Baets,Matthis Synofzik,Matthis Synofzik,Rebecca Schüle,Rebecca Schüle,Rita Horvath,Henry Houlden,Luca Bartesaghi,Hwei-Jen Lee,Konstantinos Ampatzis,Tyler Mark Pierson,Jan Senderek +118 more
TL;DR: In this paper, the authors report 25 families containing 34 individuals with neurological disease associated with biallelic 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) variants.
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FK506 Donor Pretreatment Improves Intestinal Graft Microcirculation and Morphology by Concurrent Inhibition of Early NF-κB Activation and Augmented HSP72 Synthesis
TL;DR: FK506 alleviated reperfusion injury by blocking NF-kappaB activation and ICAM-1 transcription, thus decreasing endothelial activation and improving the microcirculation, and induces Hsp72, therefore inhibiting apoptosis and accelerating morphologic restoration.