D
Dennis C. Dean
Researcher at Merck & Co.
Publications - 76
Citations - 5370
Dennis C. Dean is an academic researcher from Merck & Co.. The author has contributed to research in topics: Radioligand & Receptor. The author has an hindex of 27, co-authored 76 publications receiving 5169 citations. Previous affiliations of Dennis C. Dean include United States Military Academy.
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Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.
Journal ArticleDOI
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
Margarita Garcia-Calvo,JeanMarie Lisnock,Herbert G. Bull,Brian E. Hawes,Duane A. Burnett,Matthew P. Braun,James H. Crona,Harry R. Davis,Dennis C. Dean,Patricia A. Detmers,Michael P. Graziano,Meredith Hughes,D. Euan MacIntyre,Anthony Ogawa,Kim O’Neill,Sai Prasad N Iyer,Diane E. Shevell,Marsha Smith,Yui S. Tang,Amanda M. Makarewicz,Feroze Ujjainwalla,Scott W. Altmann,Kevin T. Chapman,Nancy A. Thornberry +23 more
TL;DR: A binding assay is developed and shown that labeled ezetimibe glucuronide binds specifically to a single site in brush border membranes and to human embryonic kidney 293 cells expressing NPC1L1, which unequivocally establish NPC1 L1 as the direct target of ezETimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport.
Journal ArticleDOI
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Kelem Kassahun,Paul G. Pearson,Wei Tang,Ian McIntosh,Kwan Leung,Charles S. Elmore,Dennis C. Dean,Regina Wang,George Doss,Thomas A. Baillie +9 more
TL;DR: The finding that metabolism of the TZD ring of troglitazone was catalyzed selectively by P450 3A enzymes is significant in light of the recent report that trog litazone is an inducer of this isoform in human hepatocytes.
Journal ArticleDOI
Identification of a new G-protein-linked receptor for growth hormone secretagogues
Sheng-Shung Pong,Lee-Yuh Chaung,Dennis C. Dean,Ravi P. Nargund,Arthur A. Patchett,Roy G. Smith +5 more
TL;DR: A specific high affinity binding site in porcine and rat anterior pituitary membranes that mediates the activity of these secretagogues has now been identified and is tightly correlated with GH-secretory activity.
Journal Article
Studies on Cytochrome P-450-Mediated Bioactivation of Diclofenac in Rats and in Human Hepatocytes: Identification of Glutathione Conjugated Metabolites
Wei Tang,Ralph A. Stearns,Stelvio M. Bandiera,Yong Zhang,Conrad E. Raab,Matthew P. Braun,Dennis C. Dean,Jianmei Pang,Kwan H. Leung,George A. Doss,John R. Strauss,Gloria Y. Kwei,Thomas H. Rushmore,Shuet Hing L Chiu,Thomas A. Baillie +14 more
TL;DR: The data suggest that diclofenac undergoes biotransformation to reactive metabolites in rats and that CYP isoforms of the 2B, 2C, and 3A subfamilies are involved in this bioactivation process.