E
Edda G. Schulz
Researcher at Max Planck Society
Publications - 28
Citations - 3875
Edda G. Schulz is an academic researcher from Max Planck Society. The author has contributed to research in topics: X-inactivation & XIST. The author has an hindex of 11, co-authored 22 publications receiving 3223 citations. Previous affiliations of Edda G. Schulz include German Cancer Research Center & French Institute of Health and Medical Research.
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Journal ArticleDOI
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Elphège P. Nora,Bryan R. Lajoie,Edda G. Schulz,Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Ikuhiro Okamoto,Ikuhiro Okamoto,Ikuhiro Okamoto,Nicolas Servant,Nicolas Servant,Nicolas Servant,Tristan Piolot,Tristan Piolot,Tristan Piolot,Nynke L. van Berkum,Johannes Meisig,John W. Sedat,Joost Gribnau,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot,Nils Blüthgen,Job Dekker,Edith Heard,Edith Heard,Edith Heard +26 more
TL;DR: In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, this study sets the stage for the full genetic dissection of the mouse X-inactivation centre.
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Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12
TL;DR: Initial polarization and subsequent imprinting of Th1 cells are mediated by interlinked, sequentially acting positive feedback loops of TCR-interferon-gamma-Stat1-T-bet and interleukin-12-Stat4-T -bet signaling.
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Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome
Simão Teixeira da Rocha,Valentina Boeva,Martin Escamilla-Del-Arenal,Katia Ancelin,Camille Granier,Neuza Reis Matias,Serena Sanulli,Jen Chow,Edda G. Schulz,Christel Picard,Syuzo Kaneko,Kristian Helin,Danny Reinberg,A. Francis Stewart,Anton Wutz,Raphaël Margueron,Edith Heard +16 more
TL;DR: It is shown that Jarid2 loss prevents efficient PRC2 and H3K27me3 enrichment to Xist-coated chromatin, and represents an important intermediate between PRC 2 and Xist RNA for the initial targeting of thePRC2 complex to the X chromosome during onset of XCI.
Journal ArticleDOI
Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes
Yinxiu Zhan,Yinxiu Zhan,Luca Mariani,Iros Barozzi,Edda G. Schulz,Nils Blüthgen,Nils Blüthgen,Michael B. Stadler,Michael B. Stadler,Guido Tiana,Luca Giorgetti +10 more
TL;DR: A novel algorithm named CaTCH is presented that identifies hierarchical trees of chromosomal domains in Hi-C maps, stratified through their reciprocal physical insulation, which is a single and biologically relevant parameter and shows that previously reported folding layers appear at different insulation levels.
Journal ArticleDOI
The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network
Edda G. Schulz,Johannes Meisig,Tomonori Nakamura,Ikuhiro Okamoto,Anja Sieber,Anja Sieber,Christel Picard,Maud Borensztein,Mitinori Saitou,Nils Blüthgen,Nils Blüthgen,Edith Heard +11 more
TL;DR: It is proposed that double X dosage interferes with differentiation, thus ensuring a tight coupling between X chromosome dosage compensation and development.