Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity
Fei Yao,Fei Yao,Jaya P. Kausalya,Yee Yen Sia,Yee Yen Sia,Audrey S. M. Teo,Audrey S. M. Teo,Wah Heng Lee,Alicia G.M. Ong,Zhenshui Zhang,Joanna H.J. Tan,Guoliang Li,Denis Bertrand,Xingliang Liu,Huay Mei Poh,Peiyong Guan,Peiyong Guan,Feng Zhu,Thushangi Nadeera Pathiraja,Thushangi Nadeera Pathiraja,Pramila N. Ariyaratne,Jaideepraj Rao,Xing Yi Woo,Shaojiang Cai,Fabianus Hendriyan Mulawadi,Wan Ting Poh,Lavanya Veeravalli,Chee Seng Chan,Seong Soo Lim,See Ting Leong,Say Chuan Neo,Poh Sum D Choi,Elaine G.Y. Chew,Niranjan Nagarajan,Pierre-Étienne Jacques,Jimmy Bok Yan So,Jimmy Bok Yan So,Xiaoan Ruan,Khay Guan Yeoh,Khay Guan Yeoh,Patrick Tan,Wing-Kin Sung,Wing-Kin Sung,Walter Hunziker,Walter Hunziker,Yijun Ruan,Axel M. Hillmer,Axel M. Hillmer +47 more
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TLDR
Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, 15 gastric cancers from Southeast Asians were analyzed and recurrent fusions between CLDN18, a tight junction gene, and ARHGAP26, a gene encoding a RHOA inhibitor were found.About:
This article is published in Cell Reports.The article was published on 2015-07-14 and is currently open access. It has received 114 citations till now. The article focuses on the topics: RHOA & Fusion gene.read more
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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
Helen H.N. Yan,Hoi Cheong Siu,Simon Law,Siu Lun Ho,Sarah S K Yue,Wai Yin Tsui,D Chan,April S. Chan,Stephanie Ma,Ka-On Lam,Sina Bartfeld,Alice H Y Man,Bernard C H Lee,Annie S Y Chan,Jason W. H. Wong,Priscilla S.W. Cheng,Anthony K W Chan,Jiangwen Zhang,Jue Shi,Xiaodan Fan,Dora Lai-Wan Kwong,Tak W. Mak,Siu Tsan Yuen,Siu Tsan Yuen,Hans Clevers,Suet Yi Leung +25 more
TL;DR: A primary gastric cancer organoid biobank that comprises normal, dysplastic, cancer, and lymph node metastases from 34 patients, including detailed whole-exome and transcriptome analysis, provides a useful resource for studying both cancer cell biology and precision cancer therapy.
Journal ArticleDOI
Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma.
TL;DR: Key challenges for the future will involve the translation of these molecular findings to clinical utility, by enabling novel strategies for early GC detection, and precision therapies for individual GC patients.
Journal ArticleDOI
Molecular classification of gastric cancer
N.-Y. Chia,P. Tan +1 more
TL;DR: This landmark study, together with other studies, has expanded the understanding on the characteristics of GC at the molecular level and may improve the medical management of GC in the future.
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Macrodomains: Structure, Function, Evolution, and Catalytic Activities
TL;DR: This review summarizes the current insights into macrodomain evolution and how this evolution influenced their structural and functional diversification and highlights some aspects of macrodomain roles in pathobiology as well as their emerging potential as therapeutic targets.
Journal ArticleDOI
ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer
Tim Chan,Aditi Qamra,Aditi Qamra,Kar Tong Tan,Jing Guo,Henry Yang,Lihua Qi,Jaymie Siqi Lin,Vanessa Hui En Ng,Yangyang Song,HuiQi Hong,Su Ting Tay,Yujing Liu,Yujing Liu,Jeeyun Lee,Sun Yong Rha,Feng Zhu,Jimmy Bok Yan So,Bin Tean Teh,Khay Guan Yeoh,Khay Guan Yeoh,Steve Rozen,Daniel G. Tenen,Daniel G. Tenen,Patrick Tan,Leilei Chen +25 more
TL;DR: A major role for RNA editing in GC disease and progression is highlighted, an observation potentially missed by previous next-generation sequencing analyses of GC focused on DNA alterations alone.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Circos: An information aesthetic for comparative genomics
Martin Krzywinski,Jacqueline E. Schein,Inanc Birol,Joseph M. Connors,Randy D. Gascoyne,Doug Horsman,Steven J.M. Jones,Marco A. Marra +7 more
TL;DR: Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements.
Journal ArticleDOI
Landscape of transcription in human cells
Sarah Djebali,Carrie A. Davis,Angelika Merkel,Alexander Dobin,Timo Lassmann,Ali Mortazavi,Ali Mortazavi,Andrea Tanzer,Julien Lagarde,Wei Lin,Felix Schlesinger,Chenghai Xue,Georgi K. Marinov,Jainab Khatun,Brian A. Williams,Chris Zaleski,Joel Rozowsky,Marion S. Röder,Felix Kokocinski,Rehab F. Abdelhamid,Tyler Alioto,Igor Antoshechkin,Michael T. Baer,Nadav Bar,Philippe Batut,Kimberly Bell,Ian Bell,Sudipto K. Chakrabortty,Xian Chen,Jacqueline Chrast,Joao Curado,Thomas Derrien,Jorg Drenkow,Erica Dumais,Jacqueline Dumais,Radha Duttagupta,Emilie Falconnet,Meagan Fastuca,Kata Fejes-Toth,Pedro G. Ferreira,Sylvain Foissac,Melissa J. Fullwood,Hui Gao,David Gonzalez,Assaf Gordon,Harsha P. Gunawardena,Cédric Howald,Sonali Jha,Rory Johnson,Philipp Kapranov,Brandon King,Colin Kingswood,Oscar Junhong Luo,Eddie Park,Kimberly Persaud,Jonathan B. Preall,Paolo Ribeca,Brian A. Risk,Daniel Robyr,Michael Sammeth,Lorian Schaffer,Lei-Hoon See,Atif Shahab,Jørgen Skancke,Ana Maria Suzuki,Hazuki Takahashi,Hagen Tilgner,Diane Trout,Nathalie Walters,Huaien Wang,John A. Wrobel,Yanbao Yu,Xiaoan Ruan,Yoshihide Hayashizaki,Jennifer Harrow,Mark Gerstein,Tim Hubbard,Alexandre Reymond,Stylianos E. Antonarakis,Gregory J. Hannon,Morgan C. Giddings,Morgan C. Giddings,Yijun Ruan,Barbara J. Wold,Piero Carninci,Roderic Guigó,Thomas R. Gingeras,Thomas R. Gingeras +87 more
TL;DR: Evidence that three-quarters of the human genome is capable of being transcribed is reported, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs that prompt a redefinition of the concept of a gene.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
Razvan Cristescu,Jeeyun Lee,Michael Nebozhyn,Kyoung-Mee Kim,Jason C. Ting,Swee Seong Wong,Jiangang Liu,Yong Gang Yue,Jian Wang,Kun Yu,Xiang S. Ye,In-Gu Do,Shawn Liu,Lara Gong,Jake Fu,Jason Gang Jin,Min Gew Choi,Tae Sung Sohn,Joon-Ho Lee,Jae Moon Bae,Seung Tae Kim,Se Hoon Park,Insuk Sohn,Sin-Ho Jung,Patrick Tan,Ronghua Chen,James S. Hardwick,Won Ki Kang,Mark Ayers,Dai Hongyue,Christoph Reinhard,Andrey Loboda,Sung Kim,Amit Aggarwal +33 more
TL;DR: This work uses gene expression data to describe four molecular subtypes linked to distinct patterns of molecular alterations, disease progression and prognosis in gastric cancer, and describes key molecular alterations in each of the four subtypes using targeted sequencing and genome-wide copy number microarrays.
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