J
Jacques Neefjes
Researcher at Leiden University Medical Center
Publications - 352
Citations - 34927
Jacques Neefjes is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: MHC class I & Antigen presentation. The author has an hindex of 95, co-authored 331 publications receiving 31500 citations. Previous affiliations of Jacques Neefjes include University of Amsterdam & Netherlands Cancer Institute.
Papers
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Journal ArticleDOI
Towards a systems understanding of MHC class I and MHC class II antigen presentation
TL;DR: A timely evaluation of the biology of antigen presentation and a survey of issues that are considered unresolved are presented.
Journal ArticleDOI
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
Eric Reits,James W. Hodge,Carla A. Herberts,Tom A.M. Groothuis,Mala Chakraborty,Elizabeth K. Wansley,Kevin Camphausen,Rosalie M. Luiten,Arnold H. de Ru,Joost Neijssen,Alexander Griekspoor,Elly Mesman,Frank A. W. Verreck,Hergen Spits,Jeffrey Schlom,Peter A. van Veelen,Jacques Neefjes +16 more
TL;DR: In this paper, the effect of irradiation on antigen presentation by MHC class I molecules was studied and it was shown that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue.
Journal ArticleDOI
Empty MHC class I molecules come out in the cold
Hans-Gustaf Ljunggren,Nico J. Stam,Claes Öhlén,Jacques Neefjes,Petter Höglund,Marie-Thérèse Heemels,J Bastin,Ton N. Schumacher,Alain Townsend,Klas Kärre +9 more
TL;DR: It is reported here that culture of the murine lymphoma mutant cell line RMA-S at reduced temperature promotes assembly, and results in a high level of cell surface expression of H-2/β2-microglobulin complexes that do not present endogenous antigens, and are labile at 37 °C.
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The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors
Ingrid Jordens,Mar Fernandez-Borja,Marije Marsman,Simone Dusseljee,Lennert Janssen,Jero Calafat,Hans Janssen,Richard Wubbolts,Jacques Neefjes +8 more
TL;DR: It is shown that RILP prevents further cycling of Rab7 and induces the recruitment of functional dynein-dynactin motor complexes to Rab7-containing late endosomes and lysosomes.
Journal ArticleDOI
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.
TL;DR: The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively.