Jeremy J. Gibson-Brown

TL;DR: Whole-genome comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also partial reconstruction of its genomic organization.

TL;DR: Examining the expression of 5 of these genes, Tbx1–Tbx5, across a wide range of embryonic stages from blastocyst through gastrulation and early organogenesis by in situ hybridization of wholemounts and tissue sections shows a good indication that the T‐box family of genes has important roles in inductive interactions in many stages of mammalian embryogenesis.

TL;DR: The results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.

TL;DR: Molecular analysis reveals that Tbx2 is required to repress chamber differentiation in the atrioventricular canal at 9.5 days post coitus (dpc), and analysis of homozygous mutants also highlights a role for TbX2 during hindlimb digit development.

TL;DR: Observations suggest that T-box genes have played a role in the evolution of fin and limb morphogenesis, and that Tbx5 and TbX4 may have been divergently selected to play a roleIn the differential specification of fore- (pectoral) versus hind- (pelvic) limb (fin) identity.