J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Postprandial plasma triglyceride and cholesterol responses to a low-fat meal
TL;DR: Low-fat (high-carbohydrate) diets are known to raise fasting TG levels in patients who do not have fasting hyperchylomicronemia, and because relatively few patients have chylomicrons in the fasting state, these data suggest that such diets may lead to day long increases in plasmaTG levels in the majority of subjects.
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Effects of Nonesterified Fatty Acids on Glucose Metabolism After Glucose Ingestion
TL;DR: In this paper, the authors investigated the role of insulin in the impaired suppression of plasma nonesterified fatty acids (NEFAs) after glucose ingestion and found that the greater insulin response compensates for the increased systemic glucose delivery by increasing peripheral glucose R d.
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C/EBPα regulates macrophage activation and systemic metabolism.
Bonggi Lee,Liping Qiao,Min Lu,Hyung sun Yoo,Wai W. Cheung,Robert H. Mak,Jerome Schaack,Gen-Sheng Feng,Nai-Wen Chi,Jerrold M. Olefsky,Jianhua Shao +10 more
TL;DR: Results imply that C/EBPα is required for macrophage activation, which plays an important role in maintaining skeletal muscle energy metabolism, and expression levels of inflammatory cytokines were reduced in skeletal muscle of HF-fed MαKO mice.
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In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.
TL;DR: Results are consistent with a role of the kinase in insulin action in vivo in humans and demonstrate the presence of a large amount of "spare kinase" for glucose disposal.
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Photoaffinity Labeling of Insulin Receptors in Viable Cultured Human Lymphocytes: Demonstration of Receptor Shedding and Degradation
TL;DR: Receptor photoaffinity labeling should provide a suitable approach for studies of the biologic fate of insulin receptors in cells that are targets for insulin action.