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Jerrold M. Olefsky

Researcher at University of California, San Diego

Publications -  606
Citations -  83310

Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.

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Journal ArticleDOI

Protein Phosphatase 2A Forms a Molecular Complex with Shc and Regulates Shc Tyrosine Phosphorylation and Downstream Mitogenic Signaling

Satoshi Ugi, +3 more
- 01 Apr 2002 - 
TL;DR: It is concluded that PP2A negatively regulates the Ras/MAP kinase pathway by binding to Shc, inhibiting tyrosine phosphorylation and that this defines a new mechanism of small-t-antigen action to promote mitogenesis.
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Induction of hypertriglyceridemia by a low-fat diet.

Henry N. Ginsberg, +4 more
- 01 Apr 1976 - 
TL;DR: The data indicate that the moderate increase in dietary CHO associated with a low fat diet will elevate plasma triglyceride levels, and it is believed that more caution is necessary before recommending the wide-spread use of low fat diets for heart disease prevention.
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Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity

Theodore P. Ciaraldi, +5 more
- 01 May 1997 - 
TL;DR: In this article, a postbinding defect in insulin signal transduction was found in polycystic ovary syndrome (PCOS) and N6-phenylisopropyl adenosine treatment was shown to normalize insulin sensitivity in obese normal cycling (NC) and PCOS subjects.
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Direct and Indirect Effects of Insulin to Inhibit Hepatic Glucose Output in Obese Subjects

Rudolf Prager, +2 more
- 01 May 1987 - 
TL;DR: In a group of insulin-resistant obese subjects, glucose-clamp studies were performed at peripheral insulin levels of 35 ± 3 μU/ml; glucose disposal did not increase, whereas HGO was suppressed by 82%, suggesting that insulin can suppress HGO through indirect extrahepatic actions.
Journal ArticleDOI

MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice.

Wei Ying, +9 more
- 06 Apr 2021 - 
TL;DR: This paper showed that miR-690 is highly expressed in M2 BMDM exosomes and functions as an insulin sensitizer both in vivo and in vitro, which could be a new therapeutic insulin-sensitizing agent for metabolic disease.