J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Amelioration of Glucose Intolerance by the Synthetic Androstene HE3286: Link to Inflammatory Pathways
Tianlun Wang,Sonia Villegas,Yujin Huang,Steve K. White,Clarence N. Ahlem,Min Lu,Jerrold M. Olefsky,Chris Reading,James M. Frincke,David G. Alleva,Jaime Flores-Riveros +10 more
TL;DR: It is suggested that HE3286 improves glucose homeostasis in diabetic and insulin-resistant mice and suggest that the observed therapeutic effects result from attenuation of proinflammatory pathways, independent of classic sex steroid receptors, corticosteroid receptors, or PPARs.
Journal ArticleDOI
Cancer-cell-secreted Extracellular Vesicles Suppress Insulin Secretion through miR-122 to Impair Systemic Glucose Homeostasis and Contribute to Tumour Growth
Minghui Cao,Roi Isaac,Wei-Mon Yan,Xianhui Ruan,Li Jiang,Yuhao Wan,Jessica Wang,Emily Wang,Christine Caron,Steve Neben,Denis Drygin,Donald P. Pizzo,Xiwei Wu,Xuxiang Liu,Andrew Chin,Miranda Y. Fong,Ziting Gao,Kaizhu Guo,Oluwole Fadare,Richard Schwab,Yuan Yuan,Susan E. Yost,Joanne E. Mortimer,Wenwan Zhong,Wei-hua Ying,Jack D. Bui,Dorothy D. Sears,Jerrold M. Olefsky,Shizhen Emily Wang +28 more
TL;DR: Cao et al. as mentioned in this paper showed that BC-derived extracellular vesicles (EVs) suppress pancreatic insulin secretion to impair glucose homeostasis and contribute to tumour growth and are abolished by inhibiting EV secretion or miR-122.
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Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated pits.
TL;DR: The results suggest that ATP binding, receptor autophosphorylation, and activation of receptor kinase activity are not required for receptor microaggregation and ligand-induced receptor-mediated internalization or the biological effects of insulin is not sufficient.
Journal ArticleDOI
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
Dorothy Sears Worrall,Jonathan E. McDunn,Benjamin List,Benjamin List,Donna Reichart,Andrea L. Hevener,Thomas A. Gustafson,Carlos F. Barbas,Richard A. Lerner,Jerrold M. Olefsky +9 more
TL;DR: It is proposed that these results are the foundation for an in vivo regulated system of insulin activation using the prohormone insulinD and catalytic antibody 38C2 with potential therapeutic application.
Journal ArticleDOI
Kinetic relationships between insulin receptor binding and effects on glucose transport in isolated rat adipocytes.
TL;DR: The role of insulin receptor occupancy in the stimulation of glucose transport has been studied in isolated rat adipocytes as mentioned in this paper, showing that a low level of insulin binding (less than 1% occupancy) is all that is necessary to initiate the insulin stimulus-response sequence.