J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats.
Jason J. Wilkes,M. T. Audrey Nguyen,Gautam Bandyopadhyay,Elizabeth Nelson,Jerrold M. Olefsky +4 more
TL;DR: Topiramate treatment prevents overall insulin resistance in HFD male Wistar rats; drug treatment improved insulin sensitivity in skeletal muscle and adipose tissue associated with enhanced AMPK phosphorylation; and the tissue "specific" effects are associated with increased serum levels of adiponectin, particularly the HMW component.
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Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors.
C M Anderson,Jerrold M. Olefsky +1 more
TL;DR: TPA-induced inhibition of insulin receptor tyrosine autophosphorylation was linked to concomitant inhibition of the biological effects of insulin in cells expressing either wild-type or COOH-terminal truncated insulin receptors.
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Effect of a glucosidase inhibitor on the metabolic response of diabetic rats to a high carbohydrate diet, consisting of starch and sucrose, or glucose.
R.Stuart Gray,Jerrold M. Olefsky +1 more
TL;DR: The therapeutic potential of BAY-g-5421 as an adjunct to the dietary management of diabetes mellitus is illustrated by a significant reduction in daily food intake of diabetic and non-diabetic rats fed diets A and B.
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Lack of effect of islet amyloid polypeptide in causing insulin resistance in conscious dogs during euglycemic clamp studies.
TL;DR: In this study, constant intravenous infusions of human islet amyloid polypeptide (hIAPP) to conscious dogs during euglycemic glucose-clamp studies raised the circulating IAPP levels 12- to 50-fold above basal levels and led to a prompt reduction in plasma calcium concentrations with intravenous administration.
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In vitro characterization of biosynthetic human proinsulin
TL;DR: Biosynthetic human proinsulin exhibits ∼ 10% of the binding and biologic potency of native insulin in adipocytes, and despite its decreased affinity for surface receptors, proins insulin is readily internalized by adipocyte, where it is degraded by a chloroquine-sensitive pathway.