J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Structural differences between insulin receptors in the brain and peripheral target tissues.
TL;DR: Structural differences, including molecular weight, antigenicity, and carbohydrate composition exist between insulin receptors in brain and peripheral target tissues.
Journal ArticleDOI
Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.
TL;DR: All of the in vitro effects of dexamethasone on glucose oxidation are due to direct inhibition of the glucose transport system, according to a direct glucocorticoid effect on the glucose Transport system.
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Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats
Hiroaki Satoh,M. T. Audrey Nguyen,Philip D.G. Miles,Takeshi Imamura,Isao Usui,Jerrold M. Olefsky +5 more
TL;DR: The results indicate that chronic "hyper-resistinemia" leads to whole-body insulin resistance involving impaired insulin signaling in skeletal muscle, liver, and adipose tissue, resulting in glucose intolerance, hyperinsulinemia, and hypertriglyceridemia.
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PPARγ and the Treatment of Insulin Resistance
TL;DR: Findings indicate that there is still much to learn about the molecular biology and physiology of these interesting receptors, and that research in this area can lead to more effective and safer drugs to treat insulin resistance and associated syndromes.
Journal ArticleDOI
SirT1 regulates adipose tissue inflammation.
Matthew P. Gillum,Maya E. Kotas,Derek M. Erion,Romy Kursawe,Paula Chatterjee,Kevin T. Nead,Eric S. Muise,Jennifer J. Hsiao,David W. Frederick,Shin Yonemitsu,Alexander S. Banks,Li-Qin Qiang,Sanjay Bhanot,Jerrold M. Olefsky,Dorothy D. Sears,Sonia Caprio,Gerald I. Shulman +16 more
TL;DR: The results suggest that SirT1 regulates adipose tissue inflammation by controlling the gain of proinflammatory transcription in response to inducers such as fatty acids, hypoxia, and endoplasmic reticulum stress.